-
Something wrong with this record ?
Delayed Effect of the Light Pulse on Phosphorylated ERK1/2 and GSK3β Kinases in the Ventrolateral Suprachiasmatic Nucleus of Rat
K. Červená, D. Pačesová, V. Spišská, Z. Bendová,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 1997-02-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1997-02-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-02-01 to 1 year ago
Psychology Database (ProQuest)
from 1997-02-01 to 1 year ago
- MeSH
- Circadian Clocks * MeSH
- Glycogen Synthase Kinase 3 metabolism MeSH
- Rats MeSH
- MAP Kinase Signaling System MeSH
- Mitogen-Activated Protein Kinase 1 metabolism MeSH
- Mitogen-Activated Protein Kinase 3 metabolism MeSH
- Suprachiasmatic Nucleus metabolism physiology MeSH
- Rats, Wistar MeSH
- Reaction Time * MeSH
- Photic Stimulation MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The intrinsic period of circadian clock in the suprachiasmatic nucleus is entrained to a 24-h cycle by external cues, mainly light. Previous studies have shown that light applied at night induces robust phosphorylation of extracellular-signal-regulated kinase that is necessary to process the light pulse into the phase shift of the clock phase. In this study, we show the persistent downregulation of phosphorylated extracellular-signal-regulated kinase and transient downregulation of phosphorylated glycogen synthase kinase-3beta in the ventrolateral part of the suprachiasmatic nucleus to photic stimuli starting at 2 h after the beginning of the light pulse. As both kinases are involved in regulation of circadian clockwork, we hypothesize that these changes may contribute to the phase-shifting effect of light at night.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16010294
- 003
- CZ-PrNML
- 005
- 20230331114550.0
- 007
- ta
- 008
- 160408s2015 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s12031-015-0563-0 $2 doi
- 024 7_
- $a 10.1007/s12031-015-0563-0 $2 doi
- 035 __
- $a (PubMed)25894767
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Červená, Kateřina $u Department of Physiology, Faculty of Science, Charles University in Prague, Viničná 7, Prague 2, 128 43, Czech Republic.
- 245 10
- $a Delayed Effect of the Light Pulse on Phosphorylated ERK1/2 and GSK3β Kinases in the Ventrolateral Suprachiasmatic Nucleus of Rat / $c K. Červená, D. Pačesová, V. Spišská, Z. Bendová,
- 520 9_
- $a The intrinsic period of circadian clock in the suprachiasmatic nucleus is entrained to a 24-h cycle by external cues, mainly light. Previous studies have shown that light applied at night induces robust phosphorylation of extracellular-signal-regulated kinase that is necessary to process the light pulse into the phase shift of the clock phase. In this study, we show the persistent downregulation of phosphorylated extracellular-signal-regulated kinase and transient downregulation of phosphorylated glycogen synthase kinase-3beta in the ventrolateral part of the suprachiasmatic nucleus to photic stimuli starting at 2 h after the beginning of the light pulse. As both kinases are involved in regulation of circadian clockwork, we hypothesize that these changes may contribute to the phase-shifting effect of light at night.
- 650 _2
- $a zvířata $7 D000818
- 650 12
- $a cirkadiánní hodiny $7 D057906
- 650 _2
- $a kinasa 3 glykogensynthasy $x metabolismus $7 D038362
- 650 _2
- $a MAP kinasový signální systém $7 D020935
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a mitogenem aktivovaná proteinkinasa 1 $x metabolismus $7 D019950
- 650 _2
- $a mitogenem aktivovaná proteinkinasa 3 $x metabolismus $7 D048052
- 650 _2
- $a světelná stimulace $7 D010775
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a potkani Wistar $7 D017208
- 650 12
- $a reakční čas $7 D011930
- 650 _2
- $a nucleus suprachiasmaticus $x metabolismus $x fyziologie $7 D013493
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Pačesová, Dominika
- 700 1_
- $a Spišská, Veronika
- 700 1_
- $a Bendová, Zdeňka
- 773 0_
- $w MED00180364 $t Journal of molecular neuroscience $x 1559-1166 $g Roč. 56, č. 2 (2015), s. 371-6
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25894767 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160408 $b ABA008
- 991 __
- $a 20230331114545 $b ABA008
- 999 __
- $a ok $b bmc $g 1113723 $s 934662
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 56 $c 2 $d 371-6 $e 20150417 $i 1559-1166 $m Journal of molecular neuroscience $n J Mol Neurosci $x MED00180364
- LZP __
- $a Pubmed-20160408
