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Developing a biomaterial interface based on poly(lactic acid) via plasma-assisted covalent anchorage of d-glucosamine and its potential for tissue regeneration
AE. Swilem, M. Lehocký, P. Humpolíček, Z. Kucekova, I. Junkar, M. Mozetič, AA. Hamed, I. Novák,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- biokompatibilní materiály chemie MeSH
- fotoelektronová spektroskopie MeSH
- glukosamin chemie MeSH
- mikroskopie atomárních sil MeSH
- polyestery chemie MeSH
- povrchové vlastnosti MeSH
- proliferace buněk MeSH
- regenerace * MeSH
- smáčivost MeSH
- tkáňové inženýrství * MeSH
- Publikační typ
- časopisecké články MeSH
The aim of this study was to develop the potential tissue engineering applications of d-glucosamine (GlcN) immobilized onto the surface of a biodegradable matrix in order to induce a desired biological effect at biointerfaces. Thus, for sample preparation we used a novel multistep physicochemical approach. In the first step the poly(lactic acid) (PLA) films were exposed to a low pressure plasma in air atmosphere, followed by radical graft copolymerization with acrylic acid to yield a carboxyl-functionalized spacer layer on the PLA surface. The carboxyl groups were then coupled to GlcN molecules via the carbodiimide chemistry. The developed surfaces were characterized by X-ray Photoelectron Spectroscopy (XPS), Contact angle measurements and Atomic Force Microscopy (AFM). A preliminary study on the proliferation of fibroblasts on the developed surfaces was performed using the NIH/3T3 cell line.
Department of Chemistry Faculty of Science Ain Shams University Abbassia Cairo 11566 Egypt
Polymer Institute Slovak Academy of Sciences Dúbravská Cesta 9 845 41 Bratislava Slovakia
Citace poskytuje Crossref.org
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