The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels
Jazyk angličtina Země Japonsko Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Erectile dysfunction, Estradiol, Sex hormone binding globulin, Testosterone, Type 1 diabetes mellitus,
- MeSH
- deprese epidemiologie psychologie MeSH
- diabetes mellitus 1. typu komplikace epidemiologie metabolismus MeSH
- diabetické nefropatie epidemiologie etiologie MeSH
- dospělí MeSH
- erektilní dysfunkce epidemiologie metabolismus psychologie MeSH
- globulin vázající pohlavní hormony metabolismus MeSH
- glykovaný hemoglobin metabolismus MeSH
- hypoglykemika terapeutické užití MeSH
- inzulin terapeutické užití MeSH
- kvalita života MeSH
- lidé MeSH
- sexuální dysfunkce fyziologická epidemiologie metabolismus psychologie MeSH
- testosteron metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- globulin vázající pohlavní hormony MeSH
- glykovaný hemoglobin MeSH
- hemoglobin A1c protein, human MeSH Prohlížeč
- hypoglykemika MeSH
- inzulin MeSH
- testosteron MeSH
Little is known about type 1 diabetes mellitus (T1DM) impact on the male sexual and reproductive functions. We aim to evaluate the influence of T1DM on male sexual function, quality of sexual life, and sex hormone levels. A total of 57 male patients aged 18 to 50 years (mean = 33) with T1DM (duration mean = 15 years) had a medical examination and completed a set of questionnaires - International Index of Erectile Function-5 (IIEF-5), Beck Depression Inventory (BDI) and Sexual quality of life questionnaire male (SQoL-M). The prevalence of erectile dysfunction was 28.1% (IIEF-5 ≤21). Patients without diabetic nephropathy had better erectile function (p = 0.008). Subjects with better glycemic control (HbA1c <65 mmol/mol) had also better erectile function (p = 0.041). At least 8.8% patients had retrograde ejaculation. Blood serum levels of sex hormones were determined and compared to laboratory reference values of healthy men. Total testosterone level was not significantly changed, sex hormone binding globulin was higher (p < 0.001) and its level correlated with daily insulin dose adjusted to body weight (p = 0.008). Free androgen index and calculated free testosterone were lower (p = 0.013; p < 0.001), estradiol was not significantly changed, LH was higher (p < 0.001), FSH was unchanged, and prolactin was higher (p < 0.001). Prostate-specific antigen (PSA) negatively correlated with HbA1c (p < 0.001). To conclude, we found significant changes in sexual functions and sex hormone blood concentrations that indicate impairment of sexual and reproductive functions in T1DM males.
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