The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels
Language English Country Japan Media print-electronic
Document type Journal Article
- Keywords
- Erectile dysfunction, Estradiol, Sex hormone binding globulin, Testosterone, Type 1 diabetes mellitus,
- MeSH
- Depression epidemiology psychology MeSH
- Diabetes Mellitus, Type 1 complications epidemiology metabolism MeSH
- Diabetic Nephropathies epidemiology etiology MeSH
- Adult MeSH
- Erectile Dysfunction epidemiology metabolism psychology MeSH
- Sex Hormone-Binding Globulin metabolism MeSH
- Glycated Hemoglobin metabolism MeSH
- Hypoglycemic Agents therapeutic use MeSH
- Insulin therapeutic use MeSH
- Quality of Life MeSH
- Humans MeSH
- Sexual Dysfunction, Physiological epidemiology metabolism psychology MeSH
- Testosterone metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Sex Hormone-Binding Globulin MeSH
- Glycated Hemoglobin A MeSH
- hemoglobin A1c protein, human MeSH Browser
- Hypoglycemic Agents MeSH
- Insulin MeSH
- Testosterone MeSH
Little is known about type 1 diabetes mellitus (T1DM) impact on the male sexual and reproductive functions. We aim to evaluate the influence of T1DM on male sexual function, quality of sexual life, and sex hormone levels. A total of 57 male patients aged 18 to 50 years (mean = 33) with T1DM (duration mean = 15 years) had a medical examination and completed a set of questionnaires - International Index of Erectile Function-5 (IIEF-5), Beck Depression Inventory (BDI) and Sexual quality of life questionnaire male (SQoL-M). The prevalence of erectile dysfunction was 28.1% (IIEF-5 ≤21). Patients without diabetic nephropathy had better erectile function (p = 0.008). Subjects with better glycemic control (HbA1c <65 mmol/mol) had also better erectile function (p = 0.041). At least 8.8% patients had retrograde ejaculation. Blood serum levels of sex hormones were determined and compared to laboratory reference values of healthy men. Total testosterone level was not significantly changed, sex hormone binding globulin was higher (p < 0.001) and its level correlated with daily insulin dose adjusted to body weight (p = 0.008). Free androgen index and calculated free testosterone were lower (p = 0.013; p < 0.001), estradiol was not significantly changed, LH was higher (p < 0.001), FSH was unchanged, and prolactin was higher (p < 0.001). Prostate-specific antigen (PSA) negatively correlated with HbA1c (p < 0.001). To conclude, we found significant changes in sexual functions and sex hormone blood concentrations that indicate impairment of sexual and reproductive functions in T1DM males.
References provided by Crossref.org
The Transgenerational Transmission of the Paternal Type 2 Diabetes-Induced Subfertility Phenotype
