Little is known about type 1 diabetes mellitus (T1DM) impact on the male sexual and reproductive functions. We aim to evaluate the influence of T1DM on male sexual function, quality of sexual life, and sex hormone levels. A total of 57 male patients aged 18 to 50 years (mean = 33) with T1DM (duration mean = 15 years) had a medical examination and completed a set of questionnaires - International Index of Erectile Function-5 (IIEF-5), Beck Depression Inventory (BDI) and Sexual quality of life questionnaire male (SQoL-M). The prevalence of erectile dysfunction was 28.1% (IIEF-5 ≤21). Patients without diabetic nephropathy had better erectile function (p = 0.008). Subjects with better glycemic control (HbA1c <65 mmol/mol) had also better erectile function (p = 0.041). At least 8.8% patients had retrograde ejaculation. Blood serum levels of sex hormones were determined and compared to laboratory reference values of healthy men. Total testosterone level was not significantly changed, sex hormone binding globulin was higher (p < 0.001) and its level correlated with daily insulin dose adjusted to body weight (p = 0.008). Free androgen index and calculated free testosterone were lower (p = 0.013; p < 0.001), estradiol was not significantly changed, LH was higher (p < 0.001), FSH was unchanged, and prolactin was higher (p < 0.001). Prostate-specific antigen (PSA) negatively correlated with HbA1c (p < 0.001). To conclude, we found significant changes in sexual functions and sex hormone blood concentrations that indicate impairment of sexual and reproductive functions in T1DM males.
- MeSH
- deprese epidemiologie psychologie MeSH
- diabetes mellitus 1. typu komplikace epidemiologie metabolismus MeSH
- diabetické nefropatie epidemiologie etiologie MeSH
- dospělí MeSH
- erektilní dysfunkce epidemiologie metabolismus psychologie MeSH
- globulin vázající pohlavní hormony metabolismus MeSH
- glykovaný hemoglobin metabolismus MeSH
- hypoglykemika terapeutické užití MeSH
- inzulin terapeutické užití MeSH
- kvalita života MeSH
- lidé MeSH
- sexuální dysfunkce fyziologická epidemiologie metabolismus psychologie MeSH
- testosteron metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- erektilní dysfunkce epidemiologie terapie MeSH
- hodnocení rizik MeSH
- inkontinence moči epidemiologie terapie MeSH
- kvalita života MeSH
- lidé MeSH
- nádory prostaty * chirurgie patologie MeSH
- pooperační komplikace etiologie MeSH
- prostatektomie metody škodlivé účinky MeSH
- striktura uretry epidemiologie terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- MeSH
- erektilní dysfunkce epidemiologie klasifikace MeSH
- inkontinence moči epidemiologie klasifikace MeSH
- kvalita života MeSH
- lidé MeSH
- nádory prostaty chirurgie MeSH
- pooperační komplikace epidemiologie klasifikace MeSH
- prostatektomie * metody škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- MeSH
- chronické selhání ledvin dietoterapie epidemiologie etiologie klasifikace MeSH
- erektilní dysfunkce epidemiologie MeSH
- hyperaktivní močový měchýř epidemiologie klasifikace MeSH
- hyperplazie prostaty epidemiologie MeSH
- nádory ledvin diagnostické zobrazování epidemiologie patologie MeSH
- nádory močového měchýře epidemiologie patologie MeSH
- nádory prostaty epidemiologie terapie MeSH
- nízkoproteinová dieta normy MeSH
- stárnutí MeSH
- urolitiáza epidemiologie terapie MeSH
- Publikační typ
- novinové články MeSH
Erectile dysfunction (ED) and diabetes mellitus (DM) share common pathophysiological risk factors including endothelial dysfunction which together with hyperglycemia contribute to the increased oxidative/glycooxidative stress. A reduced NO concentration is insufficient for relaxation processes in the penis. Chronic inflammation and endoglin are involved in the regulation of endothelial function. Adiponectin from the adipose tissue has anti-inflammatory effects. Our study aimed to investigate the relation between erectile function in patients with and without DM and the oxidative stress, hormone adiponectin, and endothelial dysfunction marker endoglin. Men (n=32) with ED evaluated by the International Index of Erectile function (IIEF-5) questionnaire (17 without DM (NDM); 15 with type 2 diabetes mellitus (DM)) and 31 controls were included. Advanced glycation end products (AGEs), 8-isoprostanes (8-isoP), protein carbonyls, antioxidant capacity, adiponectin and endoglin were determined in the blood. DM patients compared to NDM patients and controls, had increased levels of glucose, C-reactive protein, triacylglycerols, 8-isoP, AGEs, endoglin and BMI. IIEF-5 score, NO and adiponectin levels were decreased. We are the first to find out that endoglin shows a negative correlation with erectile function in NDM, but not in DM patients. Endoglin can be considered as endothelial dysfunction marker in nondiabetic men suffering from ED.
- MeSH
- adiponektin krev MeSH
- diabetes mellitus 2. typu diagnóza epidemiologie krev MeSH
- dospělí MeSH
- endoglin krev MeSH
- erektilní dysfunkce diagnóza epidemiologie krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidační stres fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
Sexuální aktivita ovlivňuje kvalitu života pacientů s kardiovaskulárním onemocněním (KVO). Cílem tohoto textu je zdůraznit fakt, že sexuální aktivita u pacientů se stabilními formami KVO tolerujících středně těžkou fyzickou zátěž je v naprosté většině případů bezpečná. Oddalování této aktivity není opodstatněné a může negativně ovlivňovat psychiku pacienta a partnerský život. Erektilní dysfunkce vaskulogenní etiologie je považována za nezávislý rizikový faktor ischemické choroby srdeční.
Sexual activity affects the quality of life of patients with cardiovascular disease (CVD). The purpose of this document is to highlight the fact that sexual activity of patients with stable forms of CVD and moderate exercise tolerance is safe. Delaying resumption of sexual activity is not justified and could have a negative impact on the patient's mental status and the quality of partners' life. Vasculogenic erectile dysfunction is considered an independent risk factor for coronary heart disease.
- MeSH
- erektilní dysfunkce epidemiologie farmakoterapie MeSH
- hodnocení rizik MeSH
- inhibitory fosfodiesterasy 5 terapeutické užití MeSH
- kardiovaskulární nemoci * epidemiologie komplikace patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- rizikové faktory MeSH
- sexuální chování fyziologie psychologie MeSH
- vaskulogenní impotence patofyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- přehledy MeSH
INTRODUCTION: This study explores the relationship between erectile function and ejaculatory function, to inform the clinical psychosexological and sexual medicine practice treatment protocols. MATERIALS AND METHODS: A total of 1,004 Czech males aged between 15 and 84 years (m = 42.8 yrs; sd = 17.6 years) completed a sexual behavior questionnaire. A cross-sectional design was adopted. Erectile function was measured with the International Index of Erectile Function (IIEF-5) and ejaculatory function measured using self-report intravaginal ejaculation latency time and the Index of Premature Ejaculation (IPE). Linear regression analyses were used to explore the relationships between premature ejaculation and erectile dysfunction. RESULTS: The sample mean self-reported intravaginal ejaculatory latency time was 9.34 minutes. The overall mean on the IPE was 19.44 (sd = 2.368). The Control domain mean was 81.13 (sd = 17.22); Sexual Satisfaction domain mean 78.60 (sd = 20.59); and the Distress domain mean was 86.86 (sd = 18.32). The mean score on the IIEF-5 was 19.28 (sd = 2.53). The results indicate a relationship between premature ejaculation and erectile dysfunction. With age significantly associated with all measures. CONCLUSIONS: Higher levels of erectile function are associated with a better control and sexual satisfaction, and less distress about ejaculation. This association supports the consideration of this relationship in the development of new clinical practice guidelines for erectile dysfunction and premature ejaculation.
- MeSH
- dospělí MeSH
- ejakulace * MeSH
- erekce penisu * MeSH
- erektilní dysfunkce epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- ochrana veřejného zdraví * MeSH
- předčasná ejakulace epidemiologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- zpráva o sobě MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- acidóza epidemiologie etiologie MeSH
- chronická renální insuficience * komplikace MeSH
- erektilní dysfunkce epidemiologie etiologie farmakoterapie MeSH
- hyperlipoproteinemie etiologie farmakoterapie MeSH
- hypertenze epidemiologie farmakoterapie MeSH
- infekční nemoci epidemiologie imunologie mikrobiologie MeSH
- inhibitory ACE farmakologie terapeutické užití MeSH
- kalcifylaxe epidemiologie etiologie MeSH
- LDL-cholesterol účinky léků MeSH
- lidé MeSH
- nemoci srdečních chlopní epidemiologie etiologie chirurgie MeSH
- onemocnění periferních arterií epidemiologie etiologie MeSH
- perikarditida epidemiologie etiologie MeSH
- srdeční arytmie farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Erectile dysfunction significantly affects quality of life in young men. Authors have evaluated erectile function in men with coronary artery disease (CAD) and the relationship between the degree of erectile dysfunction (ED) and the age of their first acute myocardial infarction (AMI). The incidence of erectile dysfunction in three groups of patients of AMI survivors was investigated: AMI survivors younger than 45 years, AMI survivors older than 65 years, and normal male population aged between 30 and 60 years. Erectile function was assessed by the International Index of Erectile Function (IIEF-5) questionnaire. In post-AMI male patients younger than 45 years ( n = 76), mild ED occurred in 26% and severe in 7%. In the older AMI group, mild ED occurred in 52% and severe in 38%. In the control group age matched to younger survivors, 96% denied ED and only one control patient had a score of 20 on the IIEF-5. A paradoxical result was observed in patients using beta blockers (BB), who had better scores than the group without BB. Statin treatment had a positive influence on the score in questionnaires. Those on statins had an average score of 21.0 ± 4.9 vs. without statin 17.7 ± 5.7, p = .03. The current findings identified that the prevalence of ED is relatively high in young patients with CAD and is related to treatment of the CAD. The overall increase in ED presence suggests that the background of their coronary event is not due to destabilization of single focused atheroma but may reflect a generalized atherosclerotic process.
- MeSH
- dospělí MeSH
- erektilní dysfunkce * epidemiologie psychologie MeSH
- infarkt myokardu * MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- přežívající * MeSH
- zdravotnické přehledy MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
