Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia

J. Šmahelová, I. Kaštánková, KM. Poláková, H. Klamová, K. Zemanová, R. Tachezy, E. Hamšíková, M. Šmahel,

. 2017 ; 37 (1) : 547-554. [pub] 20161107

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023504

Grantová podpora
NT13862 MZ0 CEP - Centrální evidence projektů

As the extent of centrosome abnormalities in chronic myeloid leukemia (CML) correlates with disease stage and karyotype alterations, abnormal expression of genes encoding centrosomal proteins may be an early prognostic marker of disease progression. In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and ESPL1) in the peripheral blood of CML patients was significantly enhanced at diagnosis and decreased to the basal level in most patients treated with imatinib mesylate for three months. In the remaining patients (17%), this decrease was delayed and was associated with worse overall survival. The detection of antibodies in sera showed that patients with higher overall antibody production had superior outcomes in terms of achieving major molecular response and failure-free survival. These data suggest that the dynamics of the response of centrosomal genes should be considered as a risk factor and immunity against centrosomal proteins may contribute to treatment response.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17023504
003      
CZ-PrNML
005      
20191029144810.0
007      
ta
008      
170720s2017 gr f 000 0|eng||
009      
AR
024    7_
$a 10.3892/or.2016.5226 $2 doi
035    __
$a (PubMed)27840977
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gr
100    1_
$a Šmahelová, Jana $u Department of Immunology, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0110565
245    10
$a Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia / $c J. Šmahelová, I. Kaštánková, KM. Poláková, H. Klamová, K. Zemanová, R. Tachezy, E. Hamšíková, M. Šmahel,
520    9_
$a As the extent of centrosome abnormalities in chronic myeloid leukemia (CML) correlates with disease stage and karyotype alterations, abnormal expression of genes encoding centrosomal proteins may be an early prognostic marker of disease progression. In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and ESPL1) in the peripheral blood of CML patients was significantly enhanced at diagnosis and decreased to the basal level in most patients treated with imatinib mesylate for three months. In the remaining patients (17%), this decrease was delayed and was associated with worse overall survival. The detection of antibodies in sera showed that patients with higher overall antibody production had superior outcomes in terms of achieving major molecular response and failure-free survival. These data suggest that the dynamics of the response of centrosomal genes should be considered as a risk factor and immunity against centrosomal proteins may contribute to treatment response.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a proteiny buněčného cyklu $x genetika $x imunologie $7 D018797
650    _2
$a centrozom $x imunologie $x metabolismus $7 D018385
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a regulace genové exprese u leukemie $7 D015973
650    _2
$a lidé $7 D006801
650    12
$a humorální imunita $x genetika $7 D056724
650    _2
$a chronická myeloidní leukemie $x genetika $x imunologie $7 D015464
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nádorové proteiny $x genetika $x imunologie $7 D009363
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kaštánková, Iva $u Department of Immunology, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic.
700    1_
$a Machová, Kateřina $u Department of Molecular Genetics, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0139783
700    1_
$a Klamová, Hana $u Clinical Department, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0081721
700    1_
$a Zemanová, Karla $u Department of Molecular Genetics, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0064009
700    1_
$a Tachezy, Ruth $u Department of Immunology, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0060363
700    1_
$a Hamšíková, Eva $u Department of Immunology, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0052821
700    1_
$a Šmahel, Michal $u Department of Immunology, Institute of Hematology and Blood Transfusion, CZ-128 20 Prague, Czech Republic. $7 xx0060364
773    0_
$w MED00179060 $t Oncology reports $x 1791-2431 $g Roč. 37, č. 1 (2017), s. 547-554
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27840977 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170720 $b ABA008
991    __
$a 20191029145249 $b ABA008
999    __
$a ok $b bmc $g 1239185 $s 984417
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 37 $c 1 $d 547-554 $e 20161107 $i 1791-2431 $m Oncology reports $n Oncol Rep $x MED00179060
GRA    __
$a NT13862 $p MZ0
LZP    __
$a Pubmed-20170720

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace