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Direct Comparison of 4 Very Early Rule-Out Strategies for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin I

J. Boeddinghaus, T. Nestelberger, R. Twerenbold, K. Wildi, P. Badertscher, J. Cupa, T. Bürge, P. Mächler, S. Corbière, K. Grimm, MR. Giménez, C. Puelacher, S. Shrestha, D. Flores Widmer, J. Fuhrmann, P. Hillinger, Z. Sabti, U. Honegger, N....

. 2017 ; 135 (17) : 1597-1611. [pub] 20170310

Jazyk angličtina Země Spojené státy americké

Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc17030973

BACKGROUND: Four strategies for very early rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy is most attractive for clinical application. METHODS: We prospectively enrolled unselected patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction. The final diagnosis was adjudicated by 2 independent cardiologists. Hs-cTnI levels were measured at presentation and after 1 hour in a blinded fashion. We directly compared all 4 hs-cTnI-based rule-out strategies: limit of detection (LOD, hs-cTnI<2 ng/L), single cutoff (hs-cTnI<5 ng/L), 1-hour algorithm (hs-cTnI<5 ng/L and 1-hour change<2 ng/L), and the 0/1-hour algorithm recommended in the European Society of Cardiology guideline combining LOD and 1-hour algorithm. RESULTS: Among 2828 enrolled patients, acute myocardial infarction was the final diagnosis in 451 (16%) patients. The LOD approach ruled out 453 patients (16%) with a sensitivity of 100% (95% confidence interval [CI], 99.2%-100%), the single cutoff 1516 patients (54%) with a sensitivity of 97.1% (95% CI, 95.1%-98.3%), the 1-hour algorithm 1459 patients (52%) with a sensitivity of 98.4% (95% CI, 96.8%-99.2%), and the 0/1-hour algorithm 1463 patients (52%) with a sensitivity of 98.4% (95% CI, 96.8%-99.2%). Predefined subgroup analysis in early presenters (≤2 hours) revealed significantly lower sensitivity (94.2%, interaction P=0.03) of the single cutoff, but not the other strategies. Two-year survival was 100% with LOD and 98.1% with the other strategies (P<0.01 for LOD versus each of the other strategies). CONCLUSIONS: All 4 rule-out strategies balance effectiveness and safety equally well. The single cutoff should not be applied in early presenters, whereas the 3 other strategies seem to perform well in this challenging subgroup. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00470587.

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$a Boeddinghaus, Jasper $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
245    10
$a Direct Comparison of 4 Very Early Rule-Out Strategies for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin I / $c J. Boeddinghaus, T. Nestelberger, R. Twerenbold, K. Wildi, P. Badertscher, J. Cupa, T. Bürge, P. Mächler, S. Corbière, K. Grimm, MR. Giménez, C. Puelacher, S. Shrestha, D. Flores Widmer, J. Fuhrmann, P. Hillinger, Z. Sabti, U. Honegger, N. Schaerli, N. Kozhuharov, K. Rentsch, Ò. Miró, B. López, FJ. Martin-Sanchez, E. Rodriguez-Adrada, B. Morawiec, D. Kawecki, E. Ganovská, J. Parenica, J. Lohrmann, W. Kloos, A. Buser, N. Geigy, DI. Keller, S. Osswald, T. Reichlin, C. Mueller,
520    9_
$a BACKGROUND: Four strategies for very early rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy is most attractive for clinical application. METHODS: We prospectively enrolled unselected patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction. The final diagnosis was adjudicated by 2 independent cardiologists. Hs-cTnI levels were measured at presentation and after 1 hour in a blinded fashion. We directly compared all 4 hs-cTnI-based rule-out strategies: limit of detection (LOD, hs-cTnI<2 ng/L), single cutoff (hs-cTnI<5 ng/L), 1-hour algorithm (hs-cTnI<5 ng/L and 1-hour change<2 ng/L), and the 0/1-hour algorithm recommended in the European Society of Cardiology guideline combining LOD and 1-hour algorithm. RESULTS: Among 2828 enrolled patients, acute myocardial infarction was the final diagnosis in 451 (16%) patients. The LOD approach ruled out 453 patients (16%) with a sensitivity of 100% (95% confidence interval [CI], 99.2%-100%), the single cutoff 1516 patients (54%) with a sensitivity of 97.1% (95% CI, 95.1%-98.3%), the 1-hour algorithm 1459 patients (52%) with a sensitivity of 98.4% (95% CI, 96.8%-99.2%), and the 0/1-hour algorithm 1463 patients (52%) with a sensitivity of 98.4% (95% CI, 96.8%-99.2%). Predefined subgroup analysis in early presenters (≤2 hours) revealed significantly lower sensitivity (94.2%, interaction P=0.03) of the single cutoff, but not the other strategies. Two-year survival was 100% with LOD and 98.1% with the other strategies (P<0.01 for LOD versus each of the other strategies). CONCLUSIONS: All 4 rule-out strategies balance effectiveness and safety equally well. The single cutoff should not be applied in early presenters, whereas the 3 other strategies seem to perform well in this challenging subgroup. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00470587.
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$a Evropa $7 D005060
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700    1_
$a Nestelberger, Thomas $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Twerenbold, Raphael $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Wildi, Karin $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Badertscher, Patrick $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Cupa, Janosch $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Bürge, Tobias $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Mächler, Patrick $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Corbière, Sydney $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Grimm, Karin $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Giménez, Maria Rubini $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Puelacher, Christian $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Shrestha, Samyut $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Flores Widmer, Dayana $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Fuhrmann, Jakob $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Hillinger, Petra $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Sabti, Zaid $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Honegger, Ursina $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Schaerli, Nicolas $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Kozhuharov, Nikola $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Rentsch, Katharina $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Miró, Òscar $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a López, Beatriz $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Martin-Sanchez, F Javier $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Rodriguez-Adrada, Esther $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Morawiec, Beata $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Kawecki, Damian $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Ganovská, Eva $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Parenica, Jiri $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Lohrmann, Jens $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Kloos, Wanda $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Buser, Andreas $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Geigy, Nicolas $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Keller, Dagmar I $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Osswald, Stefan $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Reichlin, Tobias $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.).
700    1_
$a Mueller, Christian $u From Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., R.T., K.W., P.B., J.C., T.B., P.M., S.C., K.G., M.R.G., C.P., S.S., D.F.W., J.F., P.H., Z.S., U.H., N.S., N.K., J.L. W.K., S.O., T.R., C.M.); Department of Internal Medicine, University Hospital Basel, University of Basel, Switzerland (J.B., T.N., K.G., P.H., N.S.); GREAT Network (J.B., T.N., R.T., K.W., P.B., J.C., S.C., K.G., M.R.G., C.P., S.S., D.F.W., P.H., Z.S., U.H., N.S., N.K., O.M., B.L., E.G., J.P., T.R., C.M.); Emergency Department, University Hospital Zurich, Switzerland (T.B., P.M., D.I.K.); Laboratory Medicine, University Hospital Basel, Switzerland (K.R.); Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain (O.M., B.L.); Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain (F.J.M.-S., E.R.-A.); 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland (B.M., D.K.); Department of Cardiology, University Hospital Brno, Czech Republic and Medical Faculty, Masaryk University (E.G., J.P.); Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel (A.B.); and Emergency Department, Kantonsspital Liestal, Switzerland (N.G.). christian.mueller@usb.ch.
773    0_
$w MED00001091 $t Circulation $x 1524-4539 $g Roč. 135, č. 17 (2017), s. 1597-1611
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28283497 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171031105429 $b ABA008
999    __
$a ok $b bmc $g 1254566 $s 992000
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$a 3
BAS    __
$a PreBMC
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$a 2017 $b 135 $c 17 $d 1597-1611 $e 20170310 $i 1524-4539 $m Circulation (New York, N.Y.) $n Circulation (New York) $x MED00001091
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