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Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves

RS. Affonso, JA. Lima, BM. Lessa, JVO. Caetano, MT. Obara, AB. Nóbrega, E. Nepovimova, K. Musilek, K. Kuca, GBCA. Slana, TCC. França,

. 2018 ; 32 (2) : . [pub] 20171015

Language English Country Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18010337

Grant support
NV16-34390A MZ0 CEP Register

The rise of the mosquitoes-transmitted diseases, like dengue, zika and chikungunya in Brazil in the last years has increased concerns on protection against mosquitoes bites. However, the prohibitive prices of the commercially available repellents for the majority of the Brazilian population has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of Indian clove (Syzygium aromaticum L.) as repellent, which has been reported as quite efficient by the local press. In order to verify this, we performed here the quantification of the main components of this extract through high-performance thin-layer chromatography (HPTLC)-densitometry and evaluated its efficiency as a repellent and its acetylcholinesterase (AChE) inhibition capacity. Our results have proved HPTLC-densitometry as an efficient and appropriate method for this quantification and confirmed the repellency activity, as well as its capacity of AChE inhibition.

References provided by Crossref.org

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$a The rise of the mosquitoes-transmitted diseases, like dengue, zika and chikungunya in Brazil in the last years has increased concerns on protection against mosquitoes bites. However, the prohibitive prices of the commercially available repellents for the majority of the Brazilian population has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of Indian clove (Syzygium aromaticum L.) as repellent, which has been reported as quite efficient by the local press. In order to verify this, we performed here the quantification of the main components of this extract through high-performance thin-layer chromatography (HPTLC)-densitometry and evaluated its efficiency as a repellent and its acetylcholinesterase (AChE) inhibition capacity. Our results have proved HPTLC-densitometry as an efficient and appropriate method for this quantification and confirmed the repellency activity, as well as its capacity of AChE inhibition.
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$a Lima, Josélia A $u Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Rio de Janeiro, Brazil.
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$a Caetano, João V O $u Anhanguera College of Brasília, Brazil.
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$a Obara, Marcos T $u University of Brasília, University of Brasilia, Nucleus of tropical medicine, Brazil.
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$a Nóbrega, Andréa B $u Biodiversity Chemistry Laboratory, Phytomedicine Agroecological Platform, Brazil.
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$a Musilek, Kamil $u University Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic. University Hospital, Biomedical Research Centre, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
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$a Kuca, Kamil $u University Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.
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$a Slana, Gláucia B C A $u Biodiversity Chemistry Laboratory, Phytomedicine Agroecological Platform, Brazil. National Institute of Intellectual Property, Brazil.
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$a França, Tanos C C $u Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Rio de Janeiro, Brazil. Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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