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Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Y. Hamdi, P. Soucy, KB. Kuchenbaeker, T. Pastinen, A. Droit, A. Lemaçon, J. Adlard, K. Aittomäki, IL. Andrulis, A. Arason, N. Arnold, BK. Arun, J. Azzollini, A. Bane, L. Barjhoux, D. Barrowdale, J. Benitez, P. Berthet, MJ. Blok, K. Bobolis, V....

. 2017 ; 161 (1) : 117-134. [pub] 20161028

Language English Country Netherlands

Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural

E-resources Online Full text

NLK ProQuest Central from 1997-01-01 to 1 year ago
Medline Complete (EBSCOhost) from 2005-01-01 to 1 year ago
Health & Medicine (ProQuest) from 1997-01-01 to 1 year ago
Family Health Database (ProQuest) from 1997-01-01 to 1 year ago
Public Health Database (ProQuest) from 1997-01-01 to 1 year ago

PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10-6). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance. CONCLUSION: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.

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References provided by Crossref.org

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$a Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3 / $c Y. Hamdi, P. Soucy, KB. Kuchenbaeker, T. Pastinen, A. Droit, A. Lemaçon, J. Adlard, K. Aittomäki, IL. Andrulis, A. Arason, N. Arnold, BK. Arun, J. Azzollini, A. Bane, L. Barjhoux, D. Barrowdale, J. Benitez, P. Berthet, MJ. Blok, K. Bobolis, V. Bonadona, B. Bonanni, AR. Bradbury, C. Brewer, B. Buecher, SS. Buys, MA. Caligo, J. Chiquette, WK. Chung, KB. Claes, MB. Daly, F. Damiola, R. Davidson, M. De la Hoya, K. De Leeneer, O. Diez, YC. Ding, R. Dolcetti, SM. Domchek, CM. Dorfling, D. Eccles, R. Eeles, Z. Einbeigi, B. Ejlertsen, . , C. Engel, D. Gareth Evans, L. Feliubadalo, L. Foretova, F. Fostira, WD. Foulkes, G. Fountzilas, E. Friedman, D. Frost, P. Ganschow, PA. Ganz, J. Garber, SA. Gayther, . , AM. Gerdes, G. Glendon, AK. Godwin, DE. Goldgar, MH. Greene, J. Gronwald, E. Hahnen, U. Hamann, TV. Hansen, S. Hart, JL. Hays, . , FB. Hogervorst, PJ. Hulick, EN. Imyanitov, C. Isaacs, L. Izatt, A. Jakubowska, P. James, R. Janavicius, UB. Jensen, EM. John, V. Joseph, W. Just, K. Kaczmarek, BY. Karlan, . , CM. Kets, J. Kirk, M. Kriege, Y. Laitman, M. Laurent, C. Lazaro, G. Leslie, J. Lester, F. Lesueur, A. Liljegren, N. Loman, JT. Loud, S. Manoukian, M. Mariani, S. Mazoyer, L. McGuffog, HE. Meijers-Heijboer, A. Meindl, A. Miller, M. Montagna, AM. Mulligan, KL. Nathanson, SL. Neuhausen, H. Nevanlinna, RL. Nussbaum, E. Olah, OI. Olopade, KR. Ong, JC. Oosterwijk, A. Osorio, L. Papi, SK. Park, IS. Pedersen, B. Peissel, PP. Segura, P. Peterlongo, CM. Phelan, P. Radice, J. Rantala, C. Rappaport-Fuerhauser, G. Rennert, A. Richardson, M. Robson, GC. Rodriguez, MA. Rookus, RK. Schmutzler, N. Sevenet, PD. Shah, CF. Singer, TP. Slavin, K. Snape, J. Sokolowska, IM. Sønderstrup, M. Southey, AB. Spurdle, Z. Stadler, D. Stoppa-Lyonnet, G. Sukiennicki, C. Sutter, Y. Tan, MK. Tea, MR. Teixeira, A. Teulé, SH. Teo, MB. Terry, M. Thomassen, L. Tihomirova, M. Tischkowitz, S. Tognazzo, AE. Toland, N. Tung, AM. van den Ouweland, RB. van der Luijt, K. van Engelen, EJ. van Rensburg, R. Varon-Mateeva, B. Wappenschmidt, JT. Wijnen, T. Rebbeck, G. Chenevix-Trench, K. Offit, FJ. Couch, S. Nord, DF. Easton, AC. Antoniou, J. Simard,
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$a PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10-6). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance. CONCLUSION: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.
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$a Soucy, Penny $u Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada.
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$a Adlard, Julian $u Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, LS7 4SA, UK.
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$a Azzollini, Jacopo $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy.
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$a Bane, Anita $u Department of Pathology & Molecular Medicine, Juravinski Hospital and Cancer Centre, McMaster University, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada.
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$a Barjhoux, Laure $u Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, France.
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$a Benitez, Javier $u Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain. Biomedical Network on Rare Diseases (CIBERER), 28029, Madrid, Spain. Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
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$a Berthet, Pascaline $u Centre François Baclesse, 3 avenue Général Harris, 14076, Caen, France.
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$a Blok, Marinus J $u Department of Clinical Genetics, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.
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$a Bobolis, Kristie $u City of Hope Clinical Cancer Genomics Community Research Network, 1500 East Duarte Road, Duarte, CA, 91010, USA.
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$a Bonadona, Valérie $u Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, France.
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$a Bonanni, Bernardo $u Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Via Ripamonti 435, 20141, Milan, Italy.
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$a Bradbury, Angela R $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
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$a Brewer, Carole $u Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, EX1 2ED, UK.
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$a Buecher, Bruno $u Service de Génétique Oncologique, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
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$a Buys, Saundra S $u Department of Medicine, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA.
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$a Caligo, Maria A $u Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.
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$a Chiquette, Jocelyne $u Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050 chemin Sainte-Foy, Quebec, QC, G1S 4L8, Canada.
700    1_
$a Chung, Wendy K $u Departments of Pediatrics and Medicine, Columbia University, 1150 St. Nicholas Avenue, New York, NY, 10032, USA.
700    1_
$a Claes, Kathleen B M $u Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium.
700    1_
$a Daly, Mary B $u Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
700    1_
$a Damiola, Francesca $u Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, France.
700    1_
$a Davidson, Rosemarie $u Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, G51 4TF, UK.
700    1_
$a De la Hoya, Miguel $u Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.
700    1_
$a De Leeneer, Kim $u Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium.
700    1_
$a Diez, Orland $u Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Clinical and Molecular Genetics Area, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
700    1_
$a Ding, Yuan Chun $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
700    1_
$a Dolcetti, Riccardo $u Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) National Cancer Institute, Via Franco Gallini 2, 33081, Aviano, PN, Italy. University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.
700    1_
$a Domchek, Susan M $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
700    1_
$a Dorfling, Cecilia M $u Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.
700    1_
$a Eccles, Diana $u Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Southampton, UK.
700    1_
$a Eeles, Ros $u Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, SM2 5NG, UK.
700    1_
$a Einbeigi, Zakaria $u Department of Oncology, Sahlgrenska University Hospital, 41345, Göteborg, Sweden.
700    1_
$a Ejlertsen, Bent $u Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
700    1_
$a ,
700    1_
$a Engel, Christoph $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany. LIFE, Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Gareth Evans, D $u Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, M13 9WL, UK.
700    1_
$a Feliubadalo, Lidia $u Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, L'Hospitalet, 08908, Barcelona, Spain.
700    1_
$a Foretova, Lenka $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic.
700    1_
$a Fostira, Florentia $u Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi Attikis, Athens, Greece.
700    1_
$a Foulkes, William D $u Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, QC, Canada.
700    1_
$a Fountzilas, George $u Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloníki, Greece.
700    1_
$a Friedman, Eitan $u The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel. Sackler Faculty of Medicine, Tel Aviv University, 69978, Ramat Aviv, Israel.
700    1_
$a Frost, Debra $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.
700    1_
$a Ganschow, Pamela $u Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
700    1_
$a Ganz, Patricia A $u UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA, 90095-6900, USA.
700    1_
$a Garber, Judy $u Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
700    1_
$a Gayther, Simon A $u Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
700    1_
$a ,
700    1_
$a Gerdes, Anne-Marie $u Department of Clincial Genetics, Rigshospitalet, Blegdamsvej 9, 4062, Copenhagen, Denmark.
700    1_
$a Glendon, Gord $u Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
700    1_
$a Godwin, Andrew K $u Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, Kansas City, Kansas, USA.
700    1_
$a Goldgar, David E $u Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT, 84132, USA.
700    1_
$a Greene, Mark H $u Clinical Genetics Branch, DCEG, NCI NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, USA.
700    1_
$a Gronwald, Jacek $u Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland.
700    1_
$a Hahnen, Eric $u Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931, Cologne, Germany.
700    1_
$a Hamann, Ute $u Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.
700    1_
$a Hansen, Thomas V O $u Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
700    1_
$a Hart, Steven $u Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
700    1_
$a Hays, John L $u Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, 43210, USA. Comprehensive Cancer Center Arthur C. James Cancer Hospital and Richard J. Solove Research Institute Biomedical Research Tower, Room 588, 460 West 12th Avenue, Columbus, OH, 43210, USA.
700    1_
$a ,
700    1_
$a Hogervorst, Frans B L $u Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands.
700    1_
$a Hulick, Peter J $u Center for Medical Genetics, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL, 60201, USA.
700    1_
$a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia, 197758.
700    1_
$a Isaacs, Claudine $u Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
700    1_
$a Izatt, Louise $u Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 9RT, UK.
700    1_
$a Jakubowska, Anna $u Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland.
700    1_
$a James, Paul $u Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, 3010, Australia.
700    1_
$a Janavicius, Ramunas $u Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Santariskiu st. 2, 08661, Vilnius, Lithuania. State Research Institute Centre for Innovative Medicine, Zygymantu st. 9, Vilnius, Lithuania.
700    1_
$a Jensen, Uffe Birk $u Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21C, Århus N, Denmark.
700    1_
$a John, Esther M $u Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue Suite 300, Fremont, CA, 94538, USA. Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
700    1_
$a Joseph, Vijai $u Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044, USA.
700    1_
$a Just, Walter $u Institute of Human Genetics, University of Ulm, 89091, Ulm, Germany.
700    1_
$a Kaczmarek, Katarzyna $u Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland.
700    1_
$a Karlan, Beth Y $u Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, 90048, USA.
700    1_
$a ,
700    1_
$a Kets, Carolien M $u Department of Human Genetics, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
700    1_
$a Kirk, Judy $u Westmead Hospital, Familial Cancer Service, Hawkebury Road, P.O. Box 533, Wentworthville, NSW, 2145, Australia.
700    1_
$a Kriege, Mieke $u Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands.
700    1_
$a Laitman, Yael $u The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel.
700    1_
$a Laurent, Maïté $u Service de Génétique Oncologique, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
700    1_
$a Lazaro, Conxi $u Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, L'Hospitalet, 08908, Barcelona, Spain.
700    1_
$a Leslie, Goska $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.
700    1_
$a Lester, Jenny $u Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, 90048, USA.
700    1_
$a Lesueur, Fabienne $u Genetic Epidemiology of Cancer Team, INSERM U900, Institut Curie Mines ParisTech, PSL University, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
700    1_
$a Liljegren, Annelie $u Department of Oncology, Karolinska University Hospital, 17176, Stockholm, Sweden.
700    1_
$a Loman, Niklas $u Department of Oncology, Lund University Hospital, 22185, Lund, Sweden.
700    1_
$a Loud, Jennifer T $u Clinical Genetics Branch, DCEG, NCI NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, USA.
700    1_
$a Manoukian, Siranoush $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy.
700    1_
$a Mariani, Milena $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy.
700    1_
$a Mazoyer, Sylvie $u Lyon Neuroscience Research Center-CRNL, INSERM U1028, CNRS UMR5292, University of Lyon, Lyon, France.
700    1_
$a McGuffog, Lesley $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.
700    1_
$a Meijers-Heijboer, Hanne E J $u Department of Clinical Genetics, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
700    1_
$a Meindl, Alfons $u Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Campus Kiel, 24105, Kiel, Germany.
700    1_
$a Miller, Austin $u NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY, 14263, USA.
700    1_
$a Montagna, Marco $u Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128, Padua, Italy.
700    1_
$a Mulligan, Anna Marie $u Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada.
700    1_
$a Nathanson, Katherine L $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
700    1_
$a Neuhausen, Susan L $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
700    1_
$a Nevanlinna, Heli $u Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, Haartmaninkatu 8, HUS, P.O. BOX 700, 00029, Helsinki, Finland.
700    1_
$a Nussbaum, Robert L $u Department of Medicine and Genetics, University of California, 513 Parnassus Ave., HSE 901E, San Francisco, CA, 94143-0794, USA.
700    1_
$a Olah, Edith $u Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
700    1_
$a Olopade, Olufunmilayo I $u Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 2115, Chicago, IL, USA.
700    1_
$a Ong, Kai-Ren $u West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK.
700    1_
$a Oosterwijk, Jan C $u Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands.
700    1_
$a Osorio, Ana $u Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain. Biomedical Network on Rare Diseases (CIBERER), 28029, Madrid, Spain.
700    1_
$a Papi, Laura $u Unit of Medical Genetics, Department of Biomedical Experimental and Clinical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
700    1_
$a Park, Sue Kyung $u Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea.
700    1_
$a Pedersen, Inge Sokilde $u Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Reberbansgade 15, Ålborg, Denmark.
700    1_
$a Peissel, Bernard $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy.
700    1_
$a Segura, Pedro Perez $u Department of Oncology, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.
700    1_
$a Peterlongo, Paolo $u IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO Campus, Via Adamello 16, 20139, Milan, Italy.
700    1_
$a Phelan, Catherine M $u Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
700    1_
$a Radice, Paolo $u Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab via GA Amadeo 42, 20133, Milan, Italy.
700    1_
$a Rantala, Johanna $u Department of Clinical Genetics, Karolinska University Hospital, L5:03, 171 76, Stockholm, Sweden.
700    1_
$a Rappaport-Fuerhauser, Christine $u Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria.
700    1_
$a Rennert, Gad $u Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., 34362, Haifa, Israel.
700    1_
$a Richardson, Andrea $u Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
700    1_
$a Robson, Mark $u Clinical Genetics, Services Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
700    1_
$a Rodriguez, Gustavo C $u Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, 2650 Ridge Avenue, Suite 1507, Walgreens, Evanston, IL, 60201, USA.
700    1_
$a Rookus, Matti A $u Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands.
700    1_
$a Schmutzler, Rita Katharina $u Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931, Cologne, Germany. Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, 50931, Cologne, Germany. Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany.
700    1_
$a Sevenet, Nicolas $u Oncogénétique, Institut Bergonié, 229 cours de l'Argonne, 33076, Bordeaux, France.
700    1_
$a Shah, Payal D $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
700    1_
$a Singer, Christian F $u Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria.
700    1_
$a Slavin, Thomas P $u Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
700    1_
$a Snape, Katie $u Medical Genetics Unit, St George's, University of London, London, SW17 0RE, UK.
700    1_
$a Sokolowska, Johanna $u Laboratoire de génétique médicale Nancy Université, Centre Hospitalier Régional et Universitaire, Rue du Morvan cedex 1, 54511, Vandoeuvre-les-Nancy, France.
700    1_
$a Sønderstrup, Ida Marie Heeholm $u Department of Pathology Region Zealand Section Slagelse, Slagelse Hospital, Ingemannsvej 18 Slagelse, Cpoenhagen, Denmark.
700    1_
$a Southey, Melissa $u Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC, 3010, Australia.
700    1_
$a Spurdle, Amanda B $u Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia.
700    1_
$a Stadler, Zsofia $u Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA.
700    1_
$a Stoppa-Lyonnet, Dominique $u Service de Génétique Oncologique, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
700    1_
$a Sukiennicki, Grzegorz $u Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland.
700    1_
$a Sutter, Christian $u Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
700    1_
$a Tan, Yen $u Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria.
700    1_
$a Tea, Muy-Kheng $u Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A, 1090, Vienna, Austria.
700    1_
$a Teixeira, Manuel R $u Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
700    1_
$a Teulé, Alex $u Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, L'Hospitalet, 08908, Barcelona, Spain.
700    1_
$a Teo, Soo-Hwang $u Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, 47500, Subang Jaya, Malaysia. University Malaya Cancer Research Institute, University Malaya, 1 Jalan SS12/1A, 50603, Kuala Lumpur, Malaysia.
700    1_
$a Terry, Mary Beth $u Department of Epidemiology, Columbia University, New York, NY, USA.
700    1_
$a Thomassen, Mads $u Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark.
700    1_
$a Tihomirova, Laima $u Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia.
700    1_
$a Tischkowitz, Marc $u Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, QC, Canada. Department of Medical Genetics Level 6 Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Hills Road, Box 134, Cambridge, CB2 0QQ, UK.
700    1_
$a Tognazzo, Silvia $u Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128, Padua, Italy.
700    1_
$a Toland, Amanda Ewart $u Division of Human Genetics, Departments of Internal Medicine and Cancer Biology and Genetics Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, 43210, USA.
700    1_
$a Tung, Nadine $u Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA.
700    1_
$a van den Ouweland, Ans M W $u Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, 330 Brookline Avenue, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
700    1_
$a van der Luijt, Rob B $u Department of Medical Genetics, University Medical Center Utrecht, 3584 EA, Utrecht, The Netherlands.
700    1_
$a van Engelen, Klaartje $u Department of Clinical Genetics, Academic Medical Center, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
700    1_
$a van Rensburg, Elizabeth J $u Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.
700    1_
$a Varon-Mateeva, Raymonda $u Institute of Human Genetics, Charite Berlin, Campus Virchov Klinikum, 13353, Berlin, Germany.
700    1_
$a Wappenschmidt, Barbara $u Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931, Cologne, Germany.
700    1_
$a Wijnen, Juul T $u Department of Human Genetics & Department of Clinical Genetics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.
700    1_
$a Rebbeck, Timothy $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
700    1_
$a Chenevix-Trench, Georgia $u Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia.
700    1_
$a Offit, Kenneth $u Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044, USA.
700    1_
$a Couch, Fergus J $u Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
700    1_
$a Nord, Silje $u Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0372, Oslo, Norway.
700    1_
$a Easton, Douglas F $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.
700    1_
$a Antoniou, Antonis C $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.
700    1_
$a Simard, Jacques $u Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec, QC, G1V 4G2, Canada. Jacques.Simard@crchudequebec.ulaval.ca.
773    0_
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