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Antifungal effects of the biological agent Pythium oligandrum observed in vitro

M. Načeradská, M. Fridrichová, D. Kellnerová, S. Peková, P. Lány,

. 2017 ; 19 (8) : 817-823. [pub] 20160701

Language English Country Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18017157

Objectives Dermatophytosis, commonly known as ringworm, is a superficial fungal skin disease and zoonosis. Pythium oligandrum is a micromycete with mycoparasitic properties that is used in agriculture to control fungal infections on plants. Formulations containing P oligandrum were also developed for the treatment of dermatophytoses, but only a small number of case studies have been published. In order to document the process in simplified conditions in vitro, we investigated the effectiveness of P oligandrum against three pathogenic dermatophytes common in domestic animals. Methods Cultures of the pathogens grown on nutrient media and experimentally infected cat hair were treated with P oligandrum preparations in therapeutic concentration and the changes were documented by microscopic videos and scanning electron microscopy. Results There was strong mycoparasitic activity of P oligandrum against Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes. Conclusions and relevance P oligandrum was demonstrated to be effective against three common causes of dermatophytosis in vitro.

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$a Načeradská, Martina $u 1 Department of Infectious Diseases and Microbiology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic. 2 Private Veterinary Practice for Small Animals, Prague, Czech Republic.
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$a Objectives Dermatophytosis, commonly known as ringworm, is a superficial fungal skin disease and zoonosis. Pythium oligandrum is a micromycete with mycoparasitic properties that is used in agriculture to control fungal infections on plants. Formulations containing P oligandrum were also developed for the treatment of dermatophytoses, but only a small number of case studies have been published. In order to document the process in simplified conditions in vitro, we investigated the effectiveness of P oligandrum against three pathogenic dermatophytes common in domestic animals. Methods Cultures of the pathogens grown on nutrient media and experimentally infected cat hair were treated with P oligandrum preparations in therapeutic concentration and the changes were documented by microscopic videos and scanning electron microscopy. Results There was strong mycoparasitic activity of P oligandrum against Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes. Conclusions and relevance P oligandrum was demonstrated to be effective against three common causes of dermatophytosis in vitro.
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$a Fridrichová, Michaela $u 3 Institute of Geology, Academy of Sciences, Prague, Czech Republic.
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$a Kellnerová, Dita $u 4 Sevaron, Diagnostic Laboratory, Brno, Czech Republic.
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$a Peková, Soňa $u 5 Vemodia, Laboratory for Veterinary Molecular Diagnostics, Prague, Czech Republic.
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$a Lány, Petr $u 1 Department of Infectious Diseases and Microbiology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
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