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Caveolin-1 rs4730751 gene polymorphism in kidney allograft recipients
Sylwia Słuczanowska-Głąbowska, Damian Malinowski, Krzysztof Safranow, Leszek Domański, Michał Czerewaty, Przemysław Ustianowski, Maria Laszczyńska, Andrzej Pawlik
Jazyk angličtina Země Česko
- Klíčová slova
- rs4730751,
- MeSH
- kaveolin 1 * fyziologie MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- transplantace ledvin škodlivé účinky MeSH
- transplantační imunologie * MeSH
- transplantační tolerance MeSH
- Check Tag
- lidé MeSH
Caveolin-1 is a phosphoprotein that plays a crucial role in tissue remodeling and fibrotic pathways, controlling fibroblast function, proliferation, and apoptosis. Here we aimed to examine the association between the CAV1 rs4730751 gene polymorphism and kidney graft function, graft histology, and graft survival. This study enrolled 270 Caucasian deceased – donor renal transplant recipients. We found no statistically significant associations between CAV1 rs4730751 and delayed graft function, acute rejection, or chronic allograft dysfunction, as well as creatinine values at 1–60 months after transplantation, the risk of graft loss, dialysis or death after transplantation, or histopathological changes in kidney allograft biopsies. Our findings do not support an association between the CAV1 gene rs4730751 polymorphism and kidney allograft function in our population.
Pomeranian Medical University Department of Biochemistry and Medical Chemistry Szczecin Poland
Pomeranian Medical University Department of Histology and Developmental Biology Szczecin Poland
Pomeranian Medical University Department of Perinatology Obstetrics and Gynecology Police Poland
Pomeranian Medical University Department of Physiology Szczecin Poland
Citace poskytuje Crossref.org
Literatura
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- $a Caveolin-1 is a phosphoprotein that plays a crucial role in tissue remodeling and fibrotic pathways, controlling fibroblast function, proliferation, and apoptosis. Here we aimed to examine the association between the CAV1 rs4730751 gene polymorphism and kidney graft function, graft histology, and graft survival. This study enrolled 270 Caucasian deceased – donor renal transplant recipients. We found no statistically significant associations between CAV1 rs4730751 and delayed graft function, acute rejection, or chronic allograft dysfunction, as well as creatinine values at 1–60 months after transplantation, the risk of graft loss, dialysis or death after transplantation, or histopathological changes in kidney allograft biopsies. Our findings do not support an association between the CAV1 gene rs4730751 polymorphism and kidney allograft function in our population.
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