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Nature-derived microbiota exposure as a novel immunomodulatory approach
N. Nurminen, J. Lin, M. Grönroos, R. Puhakka, L. Kramna, HK. Vari, H. Viskari, S. Oikarinen, M. Roslund, A. Parajuli, I. Tyni, O. Cinek, O. Laitinen, H. Hyöty, A. Sinkkonen,
Language English Country England, Great Britain
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
NLK
PubMed Central
from 2015 to 1 year ago
ProQuest Central
from 2006-06-01 to 2020-07-31
Nursing & Allied Health Database (ProQuest)
from 2006-06-01 to 2020-07-31
Health & Medicine (ProQuest)
from 2006-06-01 to 2020-07-31
Public Health Database (ProQuest)
from 2006-06-01 to 2020-07-31
PubMed
29771153
DOI
10.2217/fmb-2017-0286
Knihovny.cz E-resources
- MeSH
- Bacteria classification genetics isolation & purification MeSH
- Biodiversity MeSH
- Adult MeSH
- Feces microbiology MeSH
- Gastrointestinal Tract immunology microbiology MeSH
- Immunity * MeSH
- Immunomodulation MeSH
- Skin immunology microbiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Pilot Projects MeSH
- Soil chemistry MeSH
- Soil Microbiology * MeSH
- Plants microbiology MeSH
- Gastrointestinal Microbiome * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
AIM: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. MATERIALS & METHODS: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. RESULTS: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. CONCLUSION: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.
References provided by Crossref.org
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