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Optical imaging of localized chemical events using programmable diamond quantum nanosensors

T. Rendler, J. Neburkova, O. Zemek, J. Kotek, A. Zappe, Z. Chu, P. Cigler, J. Wrachtrup,

. 2017 ; 8 (-) : 14701. [pub] 20170320

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19001292

Development of multifunctional nanoscale sensors working under physiological conditions enables monitoring of intracellular processes that are important for various biological and medical applications. By attaching paramagnetic gadolinium complexes to nanodiamonds (NDs) with nitrogen-vacancy (NV) centres through surface engineering, we developed a hybrid nanoscale sensor that can be adjusted to directly monitor physiological species through a proposed sensing scheme based on NV spin relaxometry. We adopt a single-step method to measure spin relaxation rates enabling time-dependent measurements on changes in pH or redox potential at a submicrometre-length scale in a microfluidic channel that mimics cellular environments. Our experimental data are reproduced by numerical simulations of the NV spin interaction with gadolinium complexes covering the NDs. Considering the versatile engineering options provided by polymer chemistry, the underlying mechanism can be expanded to detect a variety of physiologically relevant species and variables.

Citace poskytuje Crossref.org

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$a Neburkova, Jitka $u Institute of Organic Chemistry and Biochemistry of the CAS, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic. First Faculty of Medicine, Charles University, Katerinska 32, 121 08 Prague 2, Czech Republic.
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$a Zemek, Ondrej $u Faculty of Science, Department of Inorganic Chemistry, Charles University, Hlavova 2030, 128 43, Prague 2, Czech Republic.
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$a Cigler, Petr $u Institute of Organic Chemistry and Biochemistry of the CAS, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
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