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Alteration of thiol-disulfide homeostasis in fibromyalgia syndrome

A. Tuzcu, RA. Baykara, M. Alışık, A. Omma, GK. Acet, E. Dogan, MC. Cure, F. Duygun, E. Cure, O. Erel

. 2019 ; 62 (1) : 12-18.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19030730

BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. MATERIAL AND METHODS: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel's novel methods. RESULTS: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. CONCLUSIONS: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.

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Literatura

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$a BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. MATERIAL AND METHODS: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel's novel methods. RESULTS: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. CONCLUSIONS: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.
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$a Baykara, Rabia Aydogan $u Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey
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$a Alışık, Murat $u Department of Clinical Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey
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$a Omma, Ahmet $u Division of Rheumatology, Department of Internal Medicine, Numune Education and Research Hospital, Ankara, Turkey
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$a Acet, Gunseli Karaca $u Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey
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$a Dogan, Erdal $u Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey
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$a Cure, Medine Cumhur $u Department of Biochemistry, Istanbul Laboratory, Istanbul, Turkey
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$a Duygun, Fatih $u Departments of Orthopedics and Traumatology, Antalya Training and Research Hospital, Antalya, Turkey
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$a Cure, Erkan $u Department of Internal Medicine, Camlica Erdem Hastanesi, Istanbul, Turkey
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$a Erel, Ozcan $u Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
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