-
Je něco špatně v tomto záznamu ?
Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
L. Záveský, E. Jandáková, V. Weinberger, L. Minář, V. Hanzíková, D. Dušková, LZ. Drábková, A. Hořínek,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
- MeSH
- ascitická tekutina chemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA genetika MeSH
- nádorové biomarkery genetika MeSH
- nádory vaječníků genetika patologie MeSH
- ovarium chemie MeSH
- prognóza MeSH
- regulace genové exprese u nádorů MeSH
- sekvenční analýza hybridizací s uspořádaným souborem oligonukleotidů metody MeSH
- senioři MeSH
- staging nádorů MeSH
- stanovení celkové genové exprese metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
Department of Pathology Masaryk University and University Hospital Brno Brno Czech Republic
Faculty Transfusion Center General University Hospital Prague Prague 2 Czech Republic
Institute of Experimental Botany Czech Academy of Sciences Prague 6 Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19044527
- 003
- CZ-PrNML
- 005
- 20200113104518.0
- 007
- ta
- 008
- 200109s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/07357907.2019.1663208 $2 doi
- 035 __
- $a (PubMed)31530033
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Záveský, Luděk $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague , Prague 2 , Czech Republic.
- 245 10
- $a Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers / $c L. Záveský, E. Jandáková, V. Weinberger, L. Minář, V. Hanzíková, D. Dušková, LZ. Drábková, A. Hořínek,
- 520 9_
- $a Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a ascitická tekutina $x chemie $7 D001202
- 650 _2
- $a nádorové biomarkery $x genetika $7 D014408
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a stanovení celkové genové exprese $x metody $7 D020869
- 650 _2
- $a regulace genové exprese u nádorů $7 D015972
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mikro RNA $x genetika $7 D035683
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a staging nádorů $7 D009367
- 650 _2
- $a sekvenční analýza hybridizací s uspořádaným souborem oligonukleotidů $x metody $7 D020411
- 650 _2
- $a nádory vaječníků $x genetika $x patologie $7 D010051
- 650 _2
- $a ovarium $x chemie $7 D010053
- 650 _2
- $a prognóza $7 D011379
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Jandáková, Eva $u Department of Pathology, Masaryk University and University Hospital Brno , Brno , Czech Republic.
- 700 1_
- $a Weinberger, Vít $u Department of Obstetrics and Gynecology, Masaryk University and University Hospital Brno , Brno , Czech Republic.
- 700 1_
- $a Minář, Luboš $u Department of Obstetrics and Gynecology, Masaryk University and University Hospital Brno , Brno , Czech Republic.
- 700 1_
- $a Hanzíková, Veronika $u Faculty Transfusion Center, General University Hospital in Prague , Prague 2 , Czech Republic.
- 700 1_
- $a Dušková, Daniela $u Faculty Transfusion Center, General University Hospital in Prague , Prague 2 , Czech Republic.
- 700 1_
- $a Drábková, Lenka Záveská $u Institute of Experimental Botany, Czech Academy of Sciences , Prague 6 , Czech Republic.
- 700 1_
- $a Hořínek, Aleš $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague , Prague 2 , Czech Republic. 3rd Department of Medicine, Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague , Prague 2 , Czech Republic.
- 773 0_
- $w MED00007151 $t Cancer investigation $x 1532-4192 $g Roč. 37, č. 9 (2019), s. 440-452
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31530033 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200109 $b ABA008
- 991 __
- $a 20200113104850 $b ABA008
- 999 __
- $a ok $b bmc $g 1482796 $s 1083200
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 37 $c 9 $d 440-452 $e 20190918 $i 1532-4192 $m Cancer investigation $n Cancer Invest $x MED00007151
- LZP __
- $a Pubmed-20200109
