-
Something wrong with this record ?
Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families
X. Yang, G. Leslie, A. Doroszuk, S. Schneider, J. Allen, B. Decker, AM. Dunning, J. Redman, J. Scarth, I. Plaskocinska, C. Luccarini, M. Shah, K. Pooley, L. Dorling, A. Lee, MA. Adank, J. Adlard, K. Aittomäki, IL. Andrulis, P. Ang, J. Barwell,...
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
203477/Z/16/Z
Wellcome Trust - United Kingdom
P30 CA008748
NCI NIH HHS - United States
R01 ES027121
NIEHS NIH HHS - United States
K08 CA234394
NCI NIH HHS - United States
L60 MD014321
NIMHD NIH HHS - United States
10124
Cancer Research UK - United Kingdom
NV16-29959A
MZ0
CEP Register
Digital library NLK
Full text - Article
NLK
Free Medical Journals
from 2004 to 1 year ago
Open Access Digital Library
from 1999-01-01
PubMed
31841383
DOI
10.1200/jco.19.01907
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Genetic Predisposition to Disease MeSH
- Internationality MeSH
- Middle Aged MeSH
- Humans MeSH
- Breast Neoplasms, Male genetics MeSH
- Pancreatic Neoplasms genetics MeSH
- Ovarian Neoplasms genetics MeSH
- Neoplasms genetics MeSH
- Fanconi Anemia Complementation Group N Protein genetics MeSH
- Risk MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Age Factors MeSH
- Germ-Line Mutation MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
PURPOSE: To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS: We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes. RESULTS: We found associations between PALB2 PVs and risk of female breast cancer (RR, 7.18; 95% CI, 5.82 to 8.85; P = 6.5 × 10-76), ovarian cancer (RR, 2.91; 95% CI, 1.40 to 6.04; P = 4.1 × 10-3), pancreatic cancer (RR, 2.37; 95% CI, 1.24 to 4.50; P = 8.7 × 10-3), and male breast cancer (RR, 7.34; 95% CI, 1.28 to 42.18; P = 2.6 × 10-2). There was no evidence for increased risks of prostate or colorectal cancer. The breast cancer RRs declined with age (P for trend = 2.0 × 10-3). After adjusting for family ascertainment, breast cancer risk estimates on the basis of multiple case families were similar to the estimates from families ascertained through population-based studies (P for difference = .41). On the basis of the combined data, the estimated risks to age 80 years were 53% (95% CI, 44% to 63%) for female breast cancer, 5% (95% CI, 2% to 10%) for ovarian cancer, 2%-3% (95% CI females, 1% to 4%; 95% CI males, 2% to 5%) for pancreatic cancer, and 1% (95% CI, 0.2% to 5%) for male breast cancer. CONCLUSION: These results confirm PALB2 as a major breast cancer susceptibility gene and establish substantial associations between germline PALB2 PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of PALB2 into risk prediction models and optimize the clinical cancer risk management of PALB2 PV carriers.
Ambry Genetics Aliso Viejo CA Department of Epidemiology University of California Irvine Irvine CA
Biopathologie Centre Léon Bérard Lyon France
Cancer Research Malaysia Subang Jaya Selangor Malaysia
Center for Clinical Cancer Genetics The University of Chicago Chicago IL
Centre for Medical Genetics Ghent University Ghent Belgium
City of Hope National Medical Center Duarte CA
Clinical Cancer Genomics Community Research Network City of Hope Duarte CA
Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark
Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki Finland
Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY
Department of Genetics Centre Hospitalier de l'Université de Montréal Montreal Quebec Canada
Department of Genetics University of MiamiMiller School of Medicine Miami FL
Department of Gynecology and Obstetrics Ludwig Maximilians University of Munich Munich Germany
Department of Health Sciences Research Mayo Clinic Rochester MN
Department of Human Genetics Hannover Medical School Hannover Germany
Department of Molecular Medicine University La Sapienza Rome Italy
Department of Oncology Helsinki University Hospital University of Helsinki Helsinki Finland
Department of Population Sciences Beckman Research Institute City of Hope Duarte CA
Division of Evolution and Genomic Sciences University of Manchester
Division of Oncology and Pathology Department of Clinical Sciences Lund Lund University Lund Sweden
Familial Cancer Program The University of Vermont Cancer Center Burlington VT
Genome Diagnostics Program IFOM The FIRC Institute for Molecular Oncology Milan Italy
INSERM U900 Institut Curie PSL University Mines ParisTech Paris France
Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Lawrence S Bloomberg Faculty of Nursing University of Toronto Toronto Ontario Canada
Lunenfeld Tanenbaum Research Institute of Mount Sinai Hospital Toronto Ontario Canada
Manchester Academic Health Science Centre Manchester United Kingdom
Service de Génétique Institut Curie Paris France
University of Florida Genetics Institute University of Florida Gainesville FL
Wessex Clinical Genetics Service Princess Anne Hospital Southampton United Kingdom
Yorkshire Regional Genetics Service Chapel Allerton Hospital Leeds United Kingdom
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20028451
- 003
- CZ-PrNML
- 005
- 20210114153917.0
- 007
- ta
- 008
- 210105s2020 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1200/JCO.19.01907 $2 doi
- 035 __
- $a (PubMed)31841383
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Yang, Xin $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 245 10
- $a Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families / $c X. Yang, G. Leslie, A. Doroszuk, S. Schneider, J. Allen, B. Decker, AM. Dunning, J. Redman, J. Scarth, I. Plaskocinska, C. Luccarini, M. Shah, K. Pooley, L. Dorling, A. Lee, MA. Adank, J. Adlard, K. Aittomäki, IL. Andrulis, P. Ang, J. Barwell, JL. Bernstein, K. Bobolis, Å. Borg, C. Blomqvist, KBM. Claes, P. Concannon, A. Cuggia, JO. Culver, F. Damiola, A. de Pauw, O. Diez, JS. Dolinsky, SM. Domchek, C. Engel, DG. Evans, F. Fostira, J. Garber, L. Golmard, EL. Goode, SB. Gruber, E. Hahnen, C. Hake, T. Heikkinen, JE. Hurley, R. Janavicius, Z. Kleibl, P. Kleiblova, I. Konstantopoulou, A. Kvist, H. Laduca, ASG. Lee, F. Lesueur, ER. Maher, A. Mannermaa, S. Manoukian, R. McFarland, W. McKinnon, A. Meindl, K. Metcalfe, NA. Mohd Taib, J. Moilanen, KL. Nathanson, S. Neuhausen, PS. Ng, T. Nguyen-Dumont, SM. Nielsen, F. Obermair, K. Offit, OI. Olopade, L. Ottini, J. Penkert, K. Pylkäs, P. Radice, SJ. Ramus, V. Rudaitis, L. Side, R. Silva-Smith, V. Silvestri, AB. Skytte, T. Slavin, J. Soukupova, C. Tondini, AH. Trainer, G. Unzeitig, L. Usha, T. van Overeem Hansen, J. Whitworth, M. Wood, CH. Yip, SY. Yoon, A. Yussuf, G. Zogopoulos, D. Goldgar, JL. Hopper, G. Chenevix-Trench, P. Pharoah, SHL. George, J. Balmaña, C. Houdayer, P. James, Z. El-Haffaf, H. Ehrencrona, M. Janatova, P. Peterlongo, H. Nevanlinna, R. Schmutzler, SH. Teo, M. Robson, T. Pal, F. Couch, JN. Weitzel, A. Elliott, M. Southey, R. Winqvist, DF. Easton, WD. Foulkes, AC. Antoniou, M. Tischkowitz,
- 520 9_
- $a PURPOSE: To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS: We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes. RESULTS: We found associations between PALB2 PVs and risk of female breast cancer (RR, 7.18; 95% CI, 5.82 to 8.85; P = 6.5 × 10-76), ovarian cancer (RR, 2.91; 95% CI, 1.40 to 6.04; P = 4.1 × 10-3), pancreatic cancer (RR, 2.37; 95% CI, 1.24 to 4.50; P = 8.7 × 10-3), and male breast cancer (RR, 7.34; 95% CI, 1.28 to 42.18; P = 2.6 × 10-2). There was no evidence for increased risks of prostate or colorectal cancer. The breast cancer RRs declined with age (P for trend = 2.0 × 10-3). After adjusting for family ascertainment, breast cancer risk estimates on the basis of multiple case families were similar to the estimates from families ascertained through population-based studies (P for difference = .41). On the basis of the combined data, the estimated risks to age 80 years were 53% (95% CI, 44% to 63%) for female breast cancer, 5% (95% CI, 2% to 10%) for ovarian cancer, 2%-3% (95% CI females, 1% to 4%; 95% CI males, 2% to 5%) for pancreatic cancer, and 1% (95% CI, 0.2% to 5%) for male breast cancer. CONCLUSION: These results confirm PALB2 as a major breast cancer susceptibility gene and establish substantial associations between germline PALB2 PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of PALB2 into risk prediction models and optimize the clinical cancer risk management of PALB2 PV carriers.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a věkové faktory $7 D000367
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a nádory prsu u mužů $x genetika $7 D018567
- 650 _2
- $a protein FANCN $x genetika $7 D000076164
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a genetická predispozice k nemoci $7 D020022
- 650 _2
- $a zárodečné mutace $7 D018095
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a internacionalita $7 D038622
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a nádory $x genetika $7 D009369
- 650 _2
- $a nádory vaječníků $x genetika $7 D010051
- 650 _2
- $a nádory slinivky břišní $x genetika $7 D010190
- 650 _2
- $a riziko $7 D012306
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Leslie, Goska $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Doroszuk, Alicja $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Schneider, Sandra $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Allen, Jamie $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Decker, Brennan $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. Department of Pathology, Brigham and Women's Hospital, Boston, MA.
- 700 1_
- $a Dunning, Alison M $u Centre for Cancer Genetic Epidemiology, Department of Oncology,University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Redman, James $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Scarth, James $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Plaskocinska, Inga $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Luccarini, Craig $u Centre for Cancer Genetic Epidemiology, Department of Oncology,University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Shah, Mitul $u Centre for Cancer Genetic Epidemiology, Department of Oncology,University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Pooley, Karen $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Dorling, Leila $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Lee, Andrew $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Adank, Muriel A $u Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
- 700 1_
- $a Adlard, Julian $u Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom.
- 700 1_
- $a Aittomäki, Kristiina $u Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Andrulis, Irene L $u Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
- 700 1_
- $a Ang, Peter $u Laboratory of Molecular Oncology, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.
- 700 1_
- $a Barwell, Julian $u Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
- 700 1_
- $a Bernstein, Jonine L $u Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
- 700 1_
- $a Bobolis, Kristie $u Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA.
- 700 1_
- $a Borg, Åke $u Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
- 700 1_
- $a Blomqvist, Carl $u Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Claes, Kathleen B M $u Centre for Medical Genetics, Ghent University, Ghent, Belgium.
- 700 1_
- $a Concannon, Patrick $u University of Florida Genetics Institute, University of Florida, Gainesville, FL.
- 700 1_
- $a Cuggia, Adeline $u The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. The Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
- 700 1_
- $a Culver, Julie O $u Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.
- 700 1_
- $a Damiola, Francesca $u Biopathologie, Centre Léon Bérard, Lyon, France.
- 700 1_
- $a de Pauw, Antoine $u Service de Génétique, Institut Curie, Paris, France.
- 700 1_
- $a Diez, Orland $u Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain.
- 700 1_
- $a Dolinsky, Jill S $u Ambry Genetics, Aliso Viejo, CA.
- 700 1_
- $a Domchek, Susan M $u Department ofMedicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Prospective Registry of Multiplex Testing (PROMPT), United States and Europe.
- 700 1_
- $a Engel, Christoph $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Evans, D Gareth $u Division of Evolution and Genomic Sciences, University of Manchester; Manchester Centre for Genomic Medicine, St Mary's Hospital-Manchester University Hospitals NHS Foundation Trust; and Manchester Academic Health Science Centre, Manchester, United Kingdom.
- 700 1_
- $a Fostira, Florentia $u Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos," Athens, Greece.
- 700 1_
- $a Garber, Judy $u Prospective Registry of Multiplex Testing (PROMPT), United States and Europe. Dana-Farber Cancer Institute, Boston, MA.
- 700 1_
- $a Golmard, Lisa $u Service de Génétique, Institut Curie, Paris, France.
- 700 1_
- $a Goode, Ellen L $u Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
- 700 1_
- $a Gruber, Stephen B $u City of Hope National Medical Center, Duarte, CA.
- 700 1_
- $a Hahnen, Eric $u Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
- 700 1_
- $a Hake, Christopher $u Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA.
- 700 1_
- $a Heikkinen, Tuomas $u Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Hurley, Judith E $u Division of Medical Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.
- 700 1_
- $a Janavicius, Ramunas $u Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. State Research Institute Innovative Medicine Center, Vilnius, Lithuania.
- 700 1_
- $a Kleibl, Zdenek $u Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
- 700 1_
- $a Kleiblova, Petra $u Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Konstantopoulou, Irene $u Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos," Athens, Greece.
- 700 1_
- $a Kvist, Anders $u Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
- 700 1_
- $a Laduca, Holly $u Ambry Genetics, Aliso Viejo, CA.
- 700 1_
- $a Lee, Ann S G $u Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. SingHealth Duke-NUS Oncology Academic Clinical Programme (ONCO ACP), Duke-NUS Medical School, Singapore.
- 700 1_
- $a Lesueur, Fabienne $u INSERM U900, Institut Curie, PSL University, Mines ParisTech, Paris, France.
- 700 1_
- $a Maher, Eamonn R $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Mannermaa, Arto $u Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
- 700 1_
- $a Manoukian, Siranoush $u Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
- 700 1_
- $a McFarland, Rachel $u Ambry Genetics, Aliso Viejo, CA. Department of Epidemiology, University of California, Irvine, Irvine, CA.
- 700 1_
- $a McKinnon, Wendy $u Familial Cancer Program, The University of Vermont Cancer Center, Burlington, VT.
- 700 1_
- $a Meindl, Alfons $u Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, Germany.
- 700 1_
- $a Metcalfe, Kelly $u Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Mohd Taib, Nur Aishah $u University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
- 700 1_
- $a Moilanen, Jukka $u Department of Clinical Genetics, Oulu University Hospital, Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu, Finland.
- 700 1_
- $a Nathanson, Katherine L $u Department ofMedicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
- 700 1_
- $a Neuhausen, Susan $u Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA.
- 700 1_
- $a Ng, Pei Sze $u University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. Cancer Research Malaysia, Subang Jaya Selangor, Malaysia.
- 700 1_
- $a Nguyen-Dumont, Tu $u Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
- 700 1_
- $a Nielsen, Sarah M $u Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL.
- 700 1_
- $a Obermair, Florian $u Institute of Medical Genetics, Kepler University Hospital Linz and Laboratory for Molecular Biology and Tumor Cytogenetics, Ordensklinikum Linz, Linz, Austria.
- 700 1_
- $a Offit, Kenneth $u Prospective Registry of Multiplex Testing (PROMPT), United States and Europe. Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
- 700 1_
- $a Olopade, Olufunmilayo I $u Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL.
- 700 1_
- $a Ottini, Laura $u Department of Molecular Medicine, University La Sapienza, Rome, Italy.
- 700 1_
- $a Penkert, Judith $u Department of Human Genetics, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Pylkäs, Katri $u Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre, Oulu, Finland.
- 700 1_
- $a Radice, Paolo $u Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
- 700 1_
- $a Ramus, Susan J $u School of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
- 700 1_
- $a Rudaitis, Vilius $u Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.
- 700 1_
- $a Side, Lucy $u Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom.
- 700 1_
- $a Silva-Smith, Rachel $u Department of Genetics, University of MiamiMiller School of Medicine, Miami, FL.
- 700 1_
- $a Silvestri, Valentina $u Department of Molecular Medicine, University La Sapienza, Rome, Italy.
- 700 1_
- $a Skytte, Anne-Bine $u Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
- 700 1_
- $a Slavin, Thomas $u Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA. Department of Medical Oncology, Division of Clinical Cancer Genomics, City of Hope, Duarte, CA.
- 700 1_
- $a Soukupova, Jana $u Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
- 700 1_
- $a Tondini, Carlo $u Unit of Medical Oncology, Department of Oncology and Hematology,Papa Giovanni XXIII Hospital, Bergamo, Italy.
- 700 1_
- $a Trainer, Alison H $u Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.
- 700 1_
- $a Unzeitig, Gary $u Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA.
- 700 1_
- $a Usha, Lydia $u Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA.
- 700 1_
- $a van Overeem Hansen, Thomas $u Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 700 1_
- $a Whitworth, James $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Wood, Marie $u Familial Cancer Program, The University of Vermont Cancer Center, Burlington, VT.
- 700 1_
- $a Yip, Cheng Har $u Cancer Research Malaysia, Subang Jaya Selangor, Malaysia.
- 700 1_
- $a Yoon, Sook-Yee $u Cancer Research Malaysia, Subang Jaya Selangor, Malaysia.
- 700 1_
- $a Yussuf, Amal $u Ambry Genetics, Aliso Viejo, CA.
- 700 1_
- $a Zogopoulos, George $u The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. The Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
- 700 1_
- $a Goldgar, David $u Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT.
- 700 1_
- $a Hopper, John L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Chenevix-Trench, Georgia $u Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Pharoah, Paul $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a George, Sophia H L $u Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.
- 700 1_
- $a Balmaña, Judith $u Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain. Prospective Registry of Multiplex Testing (PROMPT), United States and Europe.
- 700 1_
- $a Houdayer, Claude $u Service de Génétique, Institut Curie, Paris, France. Genetics Department, F76000 and Normandy University, UNIROUEN, INSERM U1245, Normandy Centre for Genomic and Personalized Medicine, Rouen University Hospital, Rouen, France.
- 700 1_
- $a James, Paul $u Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.
- 700 1_
- $a El-Haffaf, Zaki $u Department of Genetics, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
- 700 1_
- $a Ehrencrona, Hans $u Department of Clinical Genetics and Pathology, Department of Laboratory Medicine, Office for Medical Services, Lund, Sweden. Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
- 700 1_
- $a Janatova, Marketa $u Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
- 700 1_
- $a Peterlongo, Paolo $u Genome Diagnostics Program, IFOM-The FIRC Institute for Molecular Oncology, Milan, Italy.
- 700 1_
- $a Nevanlinna, Heli $u Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Schmutzler, Rita $u Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
- 700 1_
- $a Teo, Soo-Hwang $u University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. Cancer Research Malaysia, Subang Jaya Selangor, Malaysia.
- 700 1_
- $a Robson, Mark $u Prospective Registry of Multiplex Testing (PROMPT), United States and Europe. Breast Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
- 700 1_
- $a Pal, Tuya $u Vanderbilt-Ingram Cancer Center, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
- 700 1_
- $a Couch, Fergus $u Prospective Registry of Multiplex Testing (PROMPT), United States and Europe. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
- 700 1_
- $a Weitzel, Jeffrey N $u Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA. Department of Medical Oncology, Division of Clinical Cancer Genomics, City of Hope, Duarte, CA.
- 700 1_
- $a Elliott, Aaron $u Ambry Genetics, Aliso Viejo, CA.
- 700 1_
- $a Southey, Melissa $u Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
- 700 1_
- $a Winqvist, Robert $u Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre, Oulu, Finland.
- 700 1_
- $a Easton, Douglas F $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Foulkes, William D $u The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Departments of Human Genetics, Oncology, and Medicine, McGill University, Montreal, Quebec, Canada.
- 700 1_
- $a Antoniou, Antonis C $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
- 700 1_
- $a Tischkowitz, Marc $u Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
- 773 0_
- $w MED00002596 $t Journal of clinical oncology : official journal of the American Society of Clinical Oncology $x 1527-7755 $g Roč. 38, č. 7 (2020), s. 674-685
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31841383 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20210105 $b ABA008
- 991 __
- $a 20210114153910 $b ABA008
- 999 __
- $a ok $b bmc $g 1608786 $s 1119631
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 38 $c 7 $d 674-685 $e 20191216 $i 1527-7755 $m Journal of clinical oncology $n J. clin. Oncol. $x MED00002596
- GRA __
- $a 203477/Z/16/Z $p Wellcome Trust $2 United Kingdom
- GRA __
- $a P30 CA008748 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 ES027121 $p NIEHS NIH HHS $2 United States
- GRA __
- $a K08 CA234394 $p NCI NIH HHS $2 United States
- GRA __
- $a L60 MD014321 $p NIMHD NIH HHS $2 United States
- GRA __
- $a 10124 $p Cancer Research UK $2 United Kingdom
- GRA __
- $a NV16-29959A $p MZ0
- LZP __
- $a Pubmed-20210105
