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Insulin Signaling in Bone Marrow Adipocytes
M. Tencerova, M. Okla, M. Kassem,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Adipogenesis MeSH
- Cell Differentiation MeSH
- Bone Marrow Cells metabolism MeSH
- Glucagon-Like Peptide 1 metabolism MeSH
- Glucose metabolism MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Insulin metabolism MeSH
- Insulin Resistance MeSH
- Bone and Bones metabolism MeSH
- Bone Marrow metabolism MeSH
- Humans MeSH
- Bone Diseases, Metabolic metabolism MeSH
- Mesenchymal Stem Cells metabolism MeSH
- Obesity metabolism MeSH
- Parathyroid Hormone metabolism MeSH
- Insulin-Like Growth Factor Binding Protein 4 metabolism MeSH
- Insulin Receptor Substrate Proteins metabolism MeSH
- Receptor, Insulin metabolism MeSH
- Receptor for Advanced Glycation End Products metabolism MeSH
- Cellular Senescence * MeSH
- Adipose Tissue metabolism MeSH
- Adipocytes metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
PURPOSE OF REVIEW: The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases. RECENT FINDINGS: Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity. This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.
References provided by Crossref.org
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- $a Tencerova, Michaela $u Department of Molecular Endocrinology, KMEB, University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark. mtencerova@health.sdu.dk. Department of Molecular Physiology of Bone, Institute of Physiology, Czech Academy of Sciences, 142 20, Prague 4, Czech Republic. mtencerova@health.sdu.dk.
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- $a PURPOSE OF REVIEW: The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases. RECENT FINDINGS: Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity. This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.
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- $a Kassem, Moustapha $u Department of Molecular Endocrinology, KMEB, University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark. Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Cellular and Molecular Medicine, The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Panum Institute, University of Copenhagen, Copenhagen, Denmark.
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