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Sex Differences in Diagnosis and Diagnostic Revision of Suspected Minor Cerebral Ischemic Events

AYX. Yu, MD. Hill, N. Asdaghi, JM. Boulanger, MC. Camden, BCV. Campbell, AM. Demchuk, TS. Field, M. Goyal, M. Krause, J. Mandzia, BK. Menon, R. Mikulik, F. Moreau, AM. Penn, RH. Swartz, SB. Coutts, Diagnosis of Uncertain-Origin Benign Transient...

Yu, Amy Y X
Autor Yu, Amy Y X From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada. amyyx.yu@utoronto.ca
Hill, Michael D
Autor Hill, Michael D From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Asdaghi, Negar
Autor Asdaghi, Negar From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Boulanger, Jean-Martin
Autor Boulanger, Jean-Martin From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Camden, Marie-Christine
Autor Camden, Marie-Christine From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Campbell, Bruce C V
Autor Campbell, Bruce C V From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Demchuk, Andrew M
Autor Demchuk, Andrew M From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Field, Thalia S
Autor Field, Thalia S From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Goyal, Mayank
Autor Goyal, Mayank From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Krause, Martin
Autor Krause, Martin From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Mandzia, Jennifer
Autor Mandzia, Jennifer From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Menon, Bijoy K
Autor Menon, Bijoy K From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Mikulik, Robert
Autor Mikulik, Robert From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Moreau, Francois
Autor Moreau, Francois From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Penn, Andrew M
Autor Penn, Andrew M From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Swartz, Richard H
Autor Swartz, Richard H From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Coutts, Shelagh B
Autor Coutts, Shelagh B From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada Department of Neurology (N.A.), University of Miami, FL Department of Neurology (J.-M.B.), Sherbrooke University, Longueil Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada Northern Clinical School (M.K.), University of Sydney, Australia Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada
Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) Study Group
Autor Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) Study Group

Neurology. 2021 ; 96 (5) : e732-e739. [pub] 20201112

ISSN 1526-632X
Medvik
Zdroj

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/bmc21011512

Grantová podpora
CIHR - Canada

PubMed 33184228
DOI 10.1212/wnl.0000000000011212
Knihovny.cz E-zdroje

OBJECTIVE: To describe sex differences in the presentation, diagnosis, and revision of diagnosis after early brain MRI in patients who present with acute transient or minor neurologic events. METHODS: We performed a secondary analysis of a prospective multicenter cohort study of patients referred to neurology between 2010 and 2016 with a possible cerebrovascular event and evaluated with brain MRI within 8 days of symptom onset. Investigators documented the characteristics of the event, initial diagnosis, and final diagnosis. We used multivariable logistic regression analyses to evaluate the association between sex and outcomes. RESULTS: Among 1,028 patients (51% women, median age 63 years), more women than men reported headaches and fewer reported chest pain, but there were no sex differences in other accompanying symptoms. Women were more likely than men to be initially diagnosed with stroke mimic (54% of women vs 42% of men, adjusted odds ratio (OR) 1.60, 95% confidence interval [CI] 1.24-2.07), and women were overall less likely to have ischemia on MRI (10% vs 17%, OR 0.52, 95% CI 0.36-0.76). Among 496 patients initially diagnosed with mimic, women were less likely than men to have their diagnosis revised to minor stroke or TIA (13% vs 20%, OR 0.53, 95% CI 0.32-0.88) but were equally likely to have acute ischemia on MRI (5% vs 8%, OR 0.56, 95% CI 0.26-1.21). CONCLUSIONS: Stroke mimic was more frequently diagnosed in women than men, but diagnostic revisions were common in both. Early brain MRI is a useful addition to clinical evaluation in diagnosing transient or minor neurologic events.

Department of Clinical Neurosciences University of Calgary Alberta Canada

Department of Clinical Neurosciences Western University London Ontario Canada

Department of Medicine and Neurology University of Melbourne Parkville Australia

Department of Medicine Neurology Université de Sherbrooke Québec

Department of Neurology Sherbrooke University Longueil

Department of Neurology University of Miami FL

Department of Neurosciences Laval University Québec City Québec Canada

Division of Neurology Vancouver Island Health Authority Victoria British Columbia Canada

From the Department of Medicine University of Toronto Ontario

Neurological Department St Anne's University Hospital and Masaryk University Brno Czech Republic

Northern Clinical School University of Sydney Australia

Vancouver Stroke Program University of British Columbia Vancouver Canada

Citace poskytuje Crossref.org

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100 1_: $a Yu, Amy Y X $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada. amyyx.yu@utoronto.ca

245 10: $a Sex Differences in Diagnosis and Diagnostic Revision of Suspected Minor Cerebral Ischemic Events / $c AYX. Yu, MD. Hill, N. Asdaghi, JM. Boulanger, MC. Camden, BCV. Campbell, AM. Demchuk, TS. Field, M. Goyal, M. Krause, J. Mandzia, BK. Menon, R. Mikulik, F. Moreau, AM. Penn, RH. Swartz, SB. Coutts, Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) Study Group

520 9_: $a OBJECTIVE: To describe sex differences in the presentation, diagnosis, and revision of diagnosis after early brain MRI in patients who present with acute transient or minor neurologic events. METHODS: We performed a secondary analysis of a prospective multicenter cohort study of patients referred to neurology between 2010 and 2016 with a possible cerebrovascular event and evaluated with brain MRI within 8 days of symptom onset. Investigators documented the characteristics of the event, initial diagnosis, and final diagnosis. We used multivariable logistic regression analyses to evaluate the association between sex and outcomes. RESULTS: Among 1,028 patients (51% women, median age 63 years), more women than men reported headaches and fewer reported chest pain, but there were no sex differences in other accompanying symptoms. Women were more likely than men to be initially diagnosed with stroke mimic (54% of women vs 42% of men, adjusted odds ratio (OR) 1.60, 95% confidence interval [CI] 1.24-2.07), and women were overall less likely to have ischemia on MRI (10% vs 17%, OR 0.52, 95% CI 0.36-0.76). Among 496 patients initially diagnosed with mimic, women were less likely than men to have their diagnosis revised to minor stroke or TIA (13% vs 20%, OR 0.53, 95% CI 0.32-0.88) but were equally likely to have acute ischemia on MRI (5% vs 8%, OR 0.56, 95% CI 0.26-1.21). CONCLUSIONS: Stroke mimic was more frequently diagnosed in women than men, but diagnostic revisions were common in both. Early brain MRI is a useful addition to clinical evaluation in diagnosing transient or minor neurologic events.

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700 1_: $a Hill, Michael D $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Asdaghi, Negar $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Boulanger, Jean-Martin $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Camden, Marie-Christine $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Campbell, Bruce C V $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Demchuk, Andrew M $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Field, Thalia S $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Goyal, Mayank $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Krause, Martin $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Mandzia, Jennifer $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Menon, Bijoy K $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Mikulik, Robert $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Moreau, Francois $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Penn, Andrew M $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Swartz, Richard H $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

700 1_: $a Coutts, Shelagh B $u From the Department of Medicine (Neurology) (A.Y.X.Y., R.H.S.), University of Toronto, Ontario; Department of Clinical Neurosciences (M.D.H., A.M.D., M.G., B.K.M., S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (N.A.), University of Miami, FL; Department of Neurology (J.-M.B.), Sherbrooke University, Longueil; Department of Neurosciences (M.-C.C.), Laval University, Québec City, Québec, Canada; Department of Medicine and Neurology (B.C.V.C.), University of Melbourne, Parkville, Australia; Vancouver Stroke Program (T.S.F.), University of British Columbia, Vancouver, Canada; Northern Clinical School (M.K.), University of Sydney, Australia; Department of Clinical Neurosciences (J.M.), Western University, London, Ontario, Canada; Neurological Department (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Medicine (F.M.), Neurology, Université de Sherbrooke, Québec; and Division of Neurology (A.M.P.), Vancouver Island Health Authority, Victoria, British Columbia, Canada

710 2_: $a Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) Study Group

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856 41: $u https://pubmed.ncbi.nlm.nih.gov/33184228 $y Pubmed

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990 __: $a 20210420 $b ABA008

991 __: $a 20210507103938 $b ABA008

999 __: $a ok $b bmc $g 1650018 $s 1131891

BAS __: $a 3

BAS __: $a PreBMC

BMC __: $a 2021 $b 96 $c 5 $d e732-e739 $e 20201112 $i 1526-632X $m Neurology $n Neurology $x MED00003491

GRA __: $p CIHR $2 Canada

LZP __: $a Pubmed-20210420

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Sex Differences in Diagnosis and Diagnostic Revision of Suspected Minor Cerebral Ischemic Events

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