OBJECTIVE: To describe sex differences in the presentation, diagnosis, and revision of diagnosis after early brain MRI in patients who present with acute transient or minor neurologic events. METHODS: We performed a secondary analysis of a prospective multicenter cohort study of patients referred to neurology between 2010 and 2016 with a possible cerebrovascular event and evaluated with brain MRI within 8 days of symptom onset. Investigators documented the characteristics of the event, initial diagnosis, and final diagnosis. We used multivariable logistic regression analyses to evaluate the association between sex and outcomes. RESULTS: Among 1,028 patients (51% women, median age 63 years), more women than men reported headaches and fewer reported chest pain, but there were no sex differences in other accompanying symptoms. Women were more likely than men to be initially diagnosed with stroke mimic (54% of women vs 42% of men, adjusted odds ratio (OR) 1.60, 95% confidence interval [CI] 1.24-2.07), and women were overall less likely to have ischemia on MRI (10% vs 17%, OR 0.52, 95% CI 0.36-0.76). Among 496 patients initially diagnosed with mimic, women were less likely than men to have their diagnosis revised to minor stroke or TIA (13% vs 20%, OR 0.53, 95% CI 0.32-0.88) but were equally likely to have acute ischemia on MRI (5% vs 8%, OR 0.56, 95% CI 0.26-1.21). CONCLUSIONS: Stroke mimic was more frequently diagnosed in women than men, but diagnostic revisions were common in both. Early brain MRI is a useful addition to clinical evaluation in diagnosing transient or minor neurologic events.
- MeSH
- chybná diagnóza * MeSH
- diabetes mellitus epidemiologie MeSH
- diferenciální diagnóza * MeSH
- difuzní magnetická rezonance MeSH
- hyperlipidemie epidemiologie MeSH
- hypertenze epidemiologie MeSH
- ischemická cévní mozková příhoda diagnostické zobrazování epidemiologie patofyziologie MeSH
- ischemická choroba srdeční epidemiologie MeSH
- ischemie mozku diagnostické zobrazování epidemiologie patofyziologie MeSH
- kohortové studie MeSH
- komorbidita MeSH
- lidé středního věku MeSH
- lidé MeSH
- logistické modely MeSH
- magnetická rezonanční tomografie MeSH
- migréna diagnóza epidemiologie MeSH
- mozek diagnostické zobrazování MeSH
- multivariační analýza MeSH
- prospektivní studie MeSH
- psychický stres epidemiologie MeSH
- senioři MeSH
- sexuální faktory MeSH
- somatoformní poruchy diagnóza MeSH
- stupeň závažnosti nemoci MeSH
- tranzitorní ischemická ataka diagnostické zobrazování epidemiologie patofyziologie MeSH
- úzkostné poruchy diagnóza MeSH
- vestibulární nemoci diagnóza MeSH
- záchvaty diagnóza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH