Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction

S. Dutta, P. Sengupta, P. Slama, S. Roychoudhury

. 2021 ; 22 (18) : . [pub] 20210917

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003709

Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, "bits and pieces" of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22003709
003      
CZ-PrNML
005      
20220127145944.0
007      
ta
008      
220113s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms221810043 $2 doi
035    __
$a (PubMed)34576205
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Dutta, Sulagna $u Faculty of Dentistry, MAHSA University, Shah Alam 42610, Malaysia
245    10
$a Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction / $c S. Dutta, P. Sengupta, P. Slama, S. Roychoudhury
520    9_
$a Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, "bits and pieces" of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.
650    _2
$a cytokiny $x metabolismus $7 D016207
650    _2
$a mužské pohlavní orgány $x metabolismus $7 D005837
650    _2
$a lidé $7 D006801
650    _2
$a infertilita $x patofyziologie $7 D007246
650    _2
$a zánět $x metabolismus $x patofyziologie $7 D007249
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a oxidační stres $x genetika $x fyziologie $7 D018384
650    _2
$a reaktivní formy kyslíku $x metabolismus $7 D017382
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Sengupta, Pallav $u Faculty of Medicine, Bioscience and Nursing, MAHSA University, Shah Alam 42610, Malaysia
700    1_
$a Slama, Petr $u Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic
700    1_
$a Roychoudhury, Shubhadeep $u Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 22, č. 18 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34576205 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145940 $b ABA008
999    __
$a ok $b bmc $g 1751231 $s 1154858
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 22 $c 18 $e 20210917 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace