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Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins

A. Jakovljević, M. Tucić, M. Blažiková, A. Korenić, Y. Missirlis, V. Stamenković, P. Andjus

. 2021 ; 10 (6) : . [pub] 20210529

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004311

Grantová podpora
CA15214 European Cooperation in Science and Technology
451-03-68/2020-14/200178 Ministry of education, science and technological development of the Republic of Serbia

The extracellular matrix (ECM) of the brain plays a crucial role in providing optimal conditions for neuronal function. Interactions between neurons and a specialized form of ECM, perineuronal nets (PNN), are considered a key mechanism for the regulation of brain plasticity. Such an assembly of interconnected structural and regulatory molecules has a prominent role in the control of synaptic plasticity. In this review, we discuss novel ways of studying the interplay between PNN and its regulatory components, particularly tenascins, in the processes of synaptic plasticity, mechanotransduction, and neurogenesis. Since enhanced neuronal activity promotes PNN degradation, it is possible to study PNN remodeling as a dynamical change in the expression and organization of its constituents that is reflected in its ultrastructure. The discovery of these subtle modifications is enabled by the development of super-resolution microscopy and advanced methods of image analysis.

Citace poskytuje Crossref.org

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