-
Something wrong with this record ?
Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
C. Constantinides, LKM. Han, C. Alloza, LA. Antonucci, C. Arango, R. Ayesa-Arriola, N. Banaj, A. Bertolino, S. Borgwardt, J. Bruggemann, J. Bustillo, O. Bykhovski, V. Calhoun, V. Carr, S. Catts, YC. Chung, B. Crespo-Facorro, CM. Díaz-Caneja, G....
Language English Country England, Great Britain
Document type Meta-Analysis, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
R01 EB015611
NIBIB NIH HHS - United States
RF1 NS114628
NINDS NIH HHS - United States
RF1 MH123163
NIMH NIH HHS - United States
R01 AA012207
NIAAA NIH HHS - United States
S10 OD023696
NIH HHS - United States
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1997-01-01
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Psychology Database (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Adolescent MeSH
- Young Adult MeSH
- Brain pathology MeSH
- Prospective Studies MeSH
- Schizophrenia * MeSH
- Aged MeSH
- Aging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
3rd Faculty of Medicine Charles University Prague Czech Republic
Advanced Computation and e Science Instituto de Física de Cantabria CSIC Santander Spain
Campbell Family Mental Health Research Institute CAMH Toronto Canada
Center for the Neurobiology of Learning and Memory University of California Irvine CA USA
Centre for Youth Mental Health The University of Melbourne Melbourne VIC Australia
Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos 3 Spain
Dementia Research Centre Queen Square Institute of Neurology University College London London UK
Department of Computer Science Georgia State University Atlanta GA USA
Department of Experimental Psychopathology and Psychotherapy University of Zurich Zurich Switzerland
Department of Neuropsychiatry Seoul National University Hospital Seoul South Korea
Department of Neuroscience and Physiology SUNY Upstate Medical University Syracuse NY USA
Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA
Department of Psychiatry and Human Behavior University of California Irvine CA USA
Department of Psychiatry and Neuropsychology Maastricht University Maastricht The Netherlands
Department of Psychiatry and Psychotherapy Ludwig Maximilians Universität Munich Munich Germany
Department of Psychiatry Jeonbuk National University Hospital Jeonju Korea
Department of Psychiatry Jeonbuk National University Medical School Jeonju Korea
Department of Psychiatry Monash University Clayton VIC Australia
Department of Psychiatry Psychiatric University Hospital University of Basel Basel Switzerland
Department of Psychiatry Psychosomatics and Psychotherapy University of Lübeck Lübeck Germany
Department of Psychiatry Seoul National University College of Medicine Seoul South Korea
Department of Psychiatry Stellenbosch University Cape Town South Africa
Department of Psychiatry University of Basel Basel Switzerland
Department of Psychiatry University of California San Diego San Diego CA USA
Department of Psychiatry University of New Mexico Albuquerque NM USA
Department of Psychiatry University of Toronto Toronto ON Canada
Department of Psychology Georgia State University Atlanta GA USA
Department of Psychology School of Arts and Social Sciences City University of London London UK
Department of Psychology School of Business National College of Ireland Dublin Ireland
Department of Psychology University of Bath Bath UK
Department of Translational Biomedicine and Neuroscience University of Bari Aldo Moro Bari Italy
Division of Addiction Medicine Centre Hospitalier des Quatre Villes St Cloud France
Division of Adult Psychiatry Department of Psychiatry Geneva University Hospitals Geneva Switzerland
Faculty of Electrical Engineering Czech Technical University Prague Prague Czech Republic
FIDMAG Germanes Hospitalàries Research Foundation Barcelona Catalonia Spain
Florey Institute of Neuroscience and Mental Health Parkville VIC Australia
Hospital Benito Menni CASM Sant Boi de Llobregat Catalonia Spain
Hospital Universitario Virgen del Rocío IBiS CSIC Universidad de Sevilla Seville Spain
Hunter Medical Research Institute Newcastle NSW Australia
Institute for Translational Psychiatry University of Münster Münster Germany
Institute of Computer Science Czech Academy of Sciences Prague Czech Republic
Laboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy
Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore
Mental Health Research Center Moscow Russia
National Institute of Mental Health Klecany Czech Republic
Neuroscience Institute Georgia State University Atlanta GA USA
Neuroscience Research Australia Sydney NSW Australia
Orygen Parkville VIC Australia
Priority Research Centre for Health Behaviour The University of Newcastle Newcastle NSW Australia
Psychiatric University Hospital Zurich Zurich Switzerland
Queensland Brain Institute The University of Queensland Brisbane QLD Australia
School of Biomedical Sciences and Pharmacy University of Newcastle Newcastle NSW Australia
School of Medicine and Public Health The University of Newcastle Newcastle NSW Australia
School of Medicine University of Queensland Herston QLD Australia
School of Psychiatry University of New South Wales Sydney NSW Australia
School of Psychological Sciences University of Newcastle Callaghan NSW Australia
School of Psychology University of New South Wales Sydney NSW Australia
The Queensland Centre for Mental Health Research The University of Queensland Brisbane QLD Australia
West Region Institute of Mental Health Singapore Singapore
Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23004022
- 003
- CZ-PrNML
- 005
- 20230425141036.0
- 007
- ta
- 008
- 230418s2023 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41380-022-01897-w $2 doi
- 035 __
- $a (PubMed)36494461
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Constantinides, Constantinos $u Department of Psychology, University of Bath, Bath, UK
- 245 10
- $a Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium / $c C. Constantinides, LKM. Han, C. Alloza, LA. Antonucci, C. Arango, R. Ayesa-Arriola, N. Banaj, A. Bertolino, S. Borgwardt, J. Bruggemann, J. Bustillo, O. Bykhovski, V. Calhoun, V. Carr, S. Catts, YC. Chung, B. Crespo-Facorro, CM. Díaz-Caneja, G. Donohoe, SD. Plessis, J. Edmond, S. Ehrlich, R. Emsley, LT. Eyler, P. Fuentes-Claramonte, F. Georgiadis, M. Green, A. Guerrero-Pedraza, M. Ha, T. Hahn, FA. Henskens, L. Holleran, S. Homan, P. Homan, N. Jahanshad, J. Janssen, E. Ji, S. Kaiser, V. Kaleda, M. Kim, WS. Kim, M. Kirschner, P. Kochunov, YB. Kwak, JS. Kwon, I. Lebedeva, J. Liu, P. Mitchie, S. Michielse, D. Mothersill, B. Mowry, VO. de la Foz, C. Pantelis, G. Pergola, F. Piras, E. Pomarol-Clotet, A. Preda, Y. Quidé, PE. Rasser, K. Rootes-Murdy, R. Salvador, M. Sangiuliano, S. Sarró, U. Schall, A. Schmidt, RJ. Scott, P. Selvaggi, K. Sim, A. Skoch, G. Spalletta, F. Spaniel, SI. Thomopoulos, D. Tomecek, AS. Tomyshev, D. Tordesillas-Gutiérrez, T. van Amelsvoort, J. Vázquez-Bourgon, D. Vecchio, A. Voineskos, CS. Weickert, T. Weickert, PM. Thompson, L. Schmaal, TGM. van Erp, J. Turner, JH. Cole, ENIGMA Schizophrenia Consortium, D. Dima, E. Walton
- 520 9_
- $a Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a prospektivní studie $7 D011446
- 650 12
- $a schizofrenie $7 D012559
- 650 _2
- $a magnetická rezonanční tomografie $7 D008279
- 650 _2
- $a mozek $x patologie $7 D001921
- 650 _2
- $a stárnutí $7 D000375
- 655 _2
- $a metaanalýza $7 D017418
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Han, Laura K M $u Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia $u Orygen, Parkville, VIC, Australia $u Department of Psychiatry, Amsterdam University Medical Centers, Vrije Universiteit and GGZ inGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands
- 700 1_
- $a Alloza, Clara $u Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $1 https://orcid.org/0000000220928055
- 700 1_
- $a Antonucci, Linda Antonella $u Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy $u Department of Psychiatry and Psychotherapy, Ludwig-Maximilians Universität-Munich, Munich, Germany
- 700 1_
- $a Arango, Celso $u Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $1 https://orcid.org/0000000333824754
- 700 1_
- $a Ayesa-Arriola, Rosa $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain $1 https://orcid.org/0000000305705352
- 700 1_
- $a Banaj, Nerisa $u Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
- 700 1_
- $a Bertolino, Alessandro $u Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
- 700 1_
- $a Borgwardt, Stefan $u Department of Psychiatry (UPK), University of Basel, Basel, Switzerland $u Department of Psychiatry, Psychosomatics and Psychotherapy, University of Lübeck, Lübeck, Germany
- 700 1_
- $a Bruggemann, Jason $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia $u Neuroscience Research Australia, Sydney, NSW, Australia
- 700 1_
- $a Bustillo, Juan $u Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA $1 https://orcid.org/0000000187308152
- 700 1_
- $a Bykhovski, Oleg $u Department of Psychiatry, Psychiatric University Hospital (UPK), University of Basel, Basel, Switzerland $u Division of Addiction Medicine, Centre Hospitalier des Quatre Villes, St. Cloud, France $1 https://orcid.org/0000000175711120
- 700 1_
- $a Calhoun, Vince $u Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA $1 https://orcid.org/0000000190580747
- 700 1_
- $a Carr, Vaughan $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia $u Neuroscience Research Australia, Sydney, NSW, Australia $u Department of Psychiatry, Monash University, Clayton, VIC, Australia $1 https://orcid.org/0000000289075804
- 700 1_
- $a Catts, Stanley $u School of Medicine, University of Queensland, Herston, QLD, Australia
- 700 1_
- $a Chung, Young-Chul $u Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea $u Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea $u Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea
- 700 1_
- $a Crespo-Facorro, Benedicto $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u Hospital Universitario Virgen del Rocío, IBiS-CSIC, Universidad de Sevilla, Seville, Spain
- 700 1_
- $a Díaz-Caneja, Covadonga M $u Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $1 https://orcid.org/0000000185383175
- 700 1_
- $a Donohoe, Gary $u Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland $1 https://orcid.org/0000000330377426
- 700 1_
- $a Plessis, Stefan Du $u Department of Psychiatry, Stellenbosch University, Cape Town, South Africa $u Stellenbosch University Genomics of Brain Disorders Research Unit, South African Medical Research Council, Cape Town, South Africa
- 700 1_
- $a Edmond, Jesse $u Department of Psychology, Georgia State University, Atlanta, GA, USA
- 700 1_
- $a Ehrlich, Stefan $u Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany $1 https://orcid.org/0000000321324445
- 700 1_
- $a Emsley, Robin $u Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
- 700 1_
- $a Eyler, Lisa T $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA $u Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA
- 700 1_
- $a Fuentes-Claramonte, Paola $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain $1 https://orcid.org/0000000214287976
- 700 1_
- $a Georgiadis, Foivos $u Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland
- 700 1_
- $a Green, Melissa $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia $u Neuroscience Research Australia, Sydney, NSW, Australia $1 https://orcid.org/0000000293614874
- 700 1_
- $a Guerrero-Pedraza, Amalia $u FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain $u Hospital Benito Menni CASM, Sant Boi de Llobregat, Catalonia, Spain
- 700 1_
- $a Ha, Minji $u Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea
- 700 1_
- $a Hahn, Tim $u Institute for Translational Psychiatry, University of Münster, Münster, Germany $1 https://orcid.org/0000000165413795
- 700 1_
- $a Henskens, Frans A $u School of Medicine & Public Health, The University of Newcastle, Newcastle, NSW, Australia $u Priority Research Centre for Health Behaviour, The University of Newcastle, Newcastle, NSW, Australia $u Hunter Medical Research Institute, Newcastle, NSW, Australia $1 https://orcid.org/0000000323585630
- 700 1_
- $a Holleran, Laurena $u Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland
- 700 1_
- $a Homan, Stephanie $u Psychiatric University Hospital Zurich, Zurich, Switzerland $u Department of Experimental Psychopathology and Psychotherapy, University of Zurich, Zurich, Switzerland
- 700 1_
- $a Homan, Philipp $u Psychiatric University Hospital Zurich, Zurich, Switzerland $1 https://orcid.org/000000019034148X
- 700 1_
- $a Jahanshad, Neda $u Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
- 700 1_
- $a Janssen, Joost $u Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
- 700 1_
- $a Ji, Ellen $u Psychiatric University Hospital Zurich, Zurich, Switzerland $1 https://orcid.org/0000000315278868
- 700 1_
- $a Kaiser, Stefan $u Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland
- 700 1_
- $a Kaleda, Vasily $u Mental Health Research Center, Moscow, Russia
- 700 1_
- $a Kim, Minah $u Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea $u Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea $1 https://orcid.org/0000000186680817
- 700 1_
- $a Kim, Woo-Sung $u Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea $u Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea
- 700 1_
- $a Kirschner, Matthias $u Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland $u Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland $u McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada $1 https://orcid.org/0000000294861439
- 700 1_
- $a Kochunov, Peter $u Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
- 700 1_
- $a Kwak, Yoo Bin $u Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea
- 700 1_
- $a Kwon, Jun Soo $u Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea $u Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea $u Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea $1 https://orcid.org/0000000210601462
- 700 1_
- $a Lebedeva, Irina $u Mental Health Research Center, Moscow, Russia
- 700 1_
- $a Liu, Jingyu $u Department of Computer Science, Georgia State University, Atlanta, GA, USA $u Neuroscience Institute, Georgia State University, Atlanta, GA, USA $1 https://orcid.org/0000000217247523
- 700 1_
- $a Mitchie, Patricia $u Hunter Medical Research Institute, Newcastle, NSW, Australia $u School of Psychological Sciences, University of Newcastle, Callaghan, NSW, Australia $1 https://orcid.org/0000000241698519
- 700 1_
- $a Michielse, Stijn $u Department of Neurosurgery, School of Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands $1 https://orcid.org/0000000339308646
- 700 1_
- $a Mothersill, David $u Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland $u Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland
- 700 1_
- $a Mowry, Bryan $u Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia $u The Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD, Australia $1 https://orcid.org/0000000241155645
- 700 1_
- $a de la Foz, Víctor Ortiz-García $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain $1 https://orcid.org/0000000206271827
- 700 1_
- $a Pantelis, Christos $u Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia $u Florey Institute of Neuroscience & Mental Health, Parkville, VIC, Australia $1 https://orcid.org/0000000295650238
- 700 1_
- $a Pergola, Giulio $u Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy $1 https://orcid.org/0000000291931841
- 700 1_
- $a Piras, Fabrizio $u Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy $1 https://orcid.org/0000000335665494
- 700 1_
- $a Pomarol-Clotet, Edith $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain
- 700 1_
- $a Preda, Adrian $u Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
- 700 1_
- $a Quidé, Yann $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia $u Neuroscience Research Australia, Sydney, NSW, Australia $u School of Psychology, University of New South Wales, Sydney, NSW, Australia $1 https://orcid.org/0000000285697139
- 700 1_
- $a Rasser, Paul E $u Hunter Medical Research Institute, Newcastle, NSW, Australia $u Priority Centre for Brain & Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia
- 700 1_
- $a Rootes-Murdy, Kelly $u Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA $u Department of Psychology, Georgia State University, Atlanta, GA, USA
- 700 1_
- $a Salvador, Raymond $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain
- 700 1_
- $a Sangiuliano, Marina $u Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
- 700 1_
- $a Sarró, Salvador $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain $1 https://orcid.org/0000000318352189
- 700 1_
- $a Schall, Ulrich $u Hunter Medical Research Institute, Newcastle, NSW, Australia $u Priority Centre for Brain & Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia
- 700 1_
- $a Schmidt, André $u Department of Psychiatry (UPK), University of Basel, Basel, Switzerland $1 https://orcid.org/0000000160558397
- 700 1_
- $a Scott, Rodney J $u School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia $1 https://orcid.org/0000000177243404
- 700 1_
- $a Selvaggi, Pierluigi $u Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy $u Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
- 700 1_
- $a Sim, Kang $u West Region, Institute of Mental Health, Singapore, Singapore $u Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore $u Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
- 700 1_
- $a Skoch, Antonin $u National Institute of Mental Health, Klecany, Czech Republic $u MR unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic $1 https://orcid.org/0000000217393256 $7 xx0071615
- 700 1_
- $a Spalletta, Gianfranco $u Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy $u Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA $1 https://orcid.org/0000000274324249
- 700 1_
- $a Spaniel, Filip $u National Institute of Mental Health, Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Prague, Czech Republic $1 https://orcid.org/000000033479696X $7 xx0102926
- 700 1_
- $a Thomopoulos, Sophia I $u Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
- 700 1_
- $a Tomecek, David $u National Institute of Mental Health, Klecany, Czech Republic $u Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic $1 https://orcid.org/0000000170380529 $7 xx0228124
- 700 1_
- $a Tomyshev, Alexander S $u Mental Health Research Center, Moscow, Russia
- 700 1_
- $a Tordesillas-Gutiérrez, Diana $u Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain $u Advanced Computation and e-Science, Instituto de Física de Cantabria CSIC, Santander, Spain
- 700 1_
- $a van Amelsvoort, Therese $u Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
- 700 1_
- $a Vázquez-Bourgon, Javier $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain $u Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain $1 https://orcid.org/0000000254783376
- 700 1_
- $a Vecchio, Daniela $u Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy $1 https://orcid.org/0000000184287376
- 700 1_
- $a Voineskos, Aristotle $u Campbell Family Mental Health Research Institute, CAMH, Toronto, Canada $u Department of Psychiatry, University of Toronto, Toronto, ON, Canada $1 https://orcid.org/0000000301560395
- 700 1_
- $a Weickert, Cynthia S $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia $u Neuroscience Research Australia, Sydney, NSW, Australia $u Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
- 700 1_
- $a Weickert, Thomas $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia $u Neuroscience Research Australia, Sydney, NSW, Australia $u Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA $1 https://orcid.org/000000026408718X
- 700 1_
- $a Thompson, Paul M $u Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
- 700 1_
- $a Schmaal, Lianne $u Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia $u Orygen, Parkville, VIC, Australia $1 https://orcid.org/000000019822048X
- 700 1_
- $a van Erp, Theo G M $u Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA $u Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA $1 https://orcid.org/0000000224652797
- 700 1_
- $a Turner, Jessica $u Department of Psychology, Georgia State University, Atlanta, GA, USA $u Neuroscience Institute, Georgia State University, Atlanta, GA, USA $1 https://orcid.org/0000000300768434
- 700 1_
- $a Cole, James H $u Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK $u Dementia Research Centre, Queen Square, Institute of Neurology, University College London, London, UK
- 700 1_
- $a Dima, Danai $u Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK $u Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UK
- 700 1_
- $a Walton, Esther $u Department of Psychology, University of Bath, Bath, UK. E.Walton@bath.ac.uk $1 https://orcid.org/0000000209352200
- 710 2_
- $a ENIGMA Schizophrenia Consortium
- 773 0_
- $w MED00008047 $t Molecular psychiatry $x 1476-5578 $g Roč. 28, č. 3 (2023), s. 1201-1209
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36494461 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230418 $b ABA008
- 991 __
- $a 20230425141032 $b ABA008
- 999 __
- $a ok $b bmc $g 1924588 $s 1190231
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 28 $c 3 $d 1201-1209 $e 20221209 $i 1476-5578 $m Molecular psychiatry $n Mol Psychiatry $x MED00008047
- GRA __
- $a R01 EB015611 $p NIBIB NIH HHS $2 United States
- GRA __
- $a RF1 NS114628 $p NINDS NIH HHS $2 United States
- GRA __
- $a RF1 MH123163 $p NIMH NIH HHS $2 United States
- GRA __
- $a R01 AA012207 $p NIAAA NIH HHS $2 United States
- GRA __
- $a S10 OD023696 $p NIH HHS $2 United States
- LZP __
- $a Pubmed-20230418
