Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study

A. Morozova, F. Španiel, A. Škoch, M. Brabec, G. Zolotarov, V. Musil, P. Zach

. 2024 ; 300 (-) : 120871. [pub] 20240926

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003871

Enlarged perivascular spaces (EPVS) are increasingly recognized as an MRI detectable feature of neuroinflammatory processes and age-related neurodegenerative changes. Understanding perivascular characteristics in healthy individuals is crucial for their applicability as a reference for pathological changes. Limited data exists on the EPVS load and interhemispheric asymmetry in distribution among young healthy subjects. Despite the known impact of hydration on brain morphometric studies, blood plasma osmolality's effect on EPVS remains unexplored. This study investigated the influence of age, total intracranial volume (TIV), and blood plasma osmolality on EPVS characteristics in 59 healthy adults, each undergoing MRI and osmolality assessment twice within 14.8 months (mean ± 4 months). EPVS analysis was conducted in the centrum semiovale using high-resolution automated segmentation, followed by an optimization algorithm to enhance EPVS segmentation accuracy. Linear Mixed Effects model was used for the statistical analysis, which unveiled significant inter-individual variability in EPVS load and inter-hemispheric asymmetry. EPVS volume increased with age, higher TIV and lower blood plasma osmolality levels. Our findings offer valuable insights into EPVS characteristics among the healthy population, establishing a foundation to further explore age-related and pathological changes.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003871
003      
CZ-PrNML
005      
20250206104747.0
007      
ta
008      
250121e20240926xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.neuroimage.2024.120871 $2 doi
035    __
$a (PubMed)39341473
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Morozova, Alexandra $u Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czechia; National Institute of Mental Health, Klecany, Czechia. Electronic address: alexandra.morozova@lf3.cuni.cz
245    10
$a Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study / $c A. Morozova, F. Španiel, A. Škoch, M. Brabec, G. Zolotarov, V. Musil, P. Zach
520    9_
$a Enlarged perivascular spaces (EPVS) are increasingly recognized as an MRI detectable feature of neuroinflammatory processes and age-related neurodegenerative changes. Understanding perivascular characteristics in healthy individuals is crucial for their applicability as a reference for pathological changes. Limited data exists on the EPVS load and interhemispheric asymmetry in distribution among young healthy subjects. Despite the known impact of hydration on brain morphometric studies, blood plasma osmolality's effect on EPVS remains unexplored. This study investigated the influence of age, total intracranial volume (TIV), and blood plasma osmolality on EPVS characteristics in 59 healthy adults, each undergoing MRI and osmolality assessment twice within 14.8 months (mean ± 4 months). EPVS analysis was conducted in the centrum semiovale using high-resolution automated segmentation, followed by an optimization algorithm to enhance EPVS segmentation accuracy. Linear Mixed Effects model was used for the statistical analysis, which unveiled significant inter-individual variability in EPVS load and inter-hemispheric asymmetry. EPVS volume increased with age, higher TIV and lower blood plasma osmolality levels. Our findings offer valuable insights into EPVS characteristics among the healthy population, establishing a foundation to further explore age-related and pathological changes.
650    _2
$a lidé $7 D006801
650    _2
$a osmolární koncentrace $7 D009994
650    _2
$a dospělí $7 D000328
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    12
$a magnetická rezonanční tomografie $x metody $7 D008279
650    _2
$a longitudinální studie $7 D008137
650    _2
$a lidé středního věku $7 D008875
650    12
$a mozek $x diagnostické zobrazování $x patologie $7 D001921
650    _2
$a mladý dospělý $7 D055815
650    12
$a glymfatický systém $x diagnostické zobrazování $x patologie $7 D000077502
650    _2
$a senioři $7 D000368
655    _2
$a časopisecké články $7 D016428
700    1_
$a Španiel, Filip $u National Institute of Mental Health, Klecany, Czechia
700    1_
$a Škoch, Antonín $u National Institute of Mental Health, Klecany, Czechia
700    1_
$a Brabec, Marek $u Department of Statistical Modeling, Institute of Computer Science, Academy of Sciences of the Czech Republic, Prague, Czechia
700    1_
$a Zolotarov, Grygoriy $u Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain; Pompeu Fabra University, Barcelona, Spain
700    1_
$a Musil, Vladimir $u Centre of Scientific Information, Third Faculty of Medicine, Charles University, Prague, Czechia
700    1_
$a Zach, Petr $u Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czechia; National Institute of Mental Health, Klecany, Czechia
773    0_
$w MED00006575 $t NeuroImage $x 1095-9572 $g Roč. 300 (20240926), s. 120871
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39341473 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104743 $b ABA008
999    __
$a ok $b bmc $g 2263561 $s 1239878
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 300 $c - $d 120871 $e 20240926 $i 1095-9572 $m NeuroImage $n Neuroimage $x MED00006575
LZP    __
$a Pubmed-20250121

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...