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Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study
A. Morozova, F. Španiel, A. Škoch, M. Brabec, G. Zolotarov, V. Musil, P. Zach
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2020
ProQuest Central
od 1998-05-01 do Před 2 měsíci
Health & Medicine (ProQuest)
od 2002-08-01 do Před 2 měsíci
Psychology Database (ProQuest)
od 2002-08-01 do Před 2 měsíci
ROAD: Directory of Open Access Scholarly Resources
- MeSH
- dospělí MeSH
- glymfatický systém * diagnostické zobrazování patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- magnetická rezonanční tomografie * metody MeSH
- mladý dospělý MeSH
- mozek * diagnostické zobrazování patologie MeSH
- osmolární koncentrace MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Enlarged perivascular spaces (EPVS) are increasingly recognized as an MRI detectable feature of neuroinflammatory processes and age-related neurodegenerative changes. Understanding perivascular characteristics in healthy individuals is crucial for their applicability as a reference for pathological changes. Limited data exists on the EPVS load and interhemispheric asymmetry in distribution among young healthy subjects. Despite the known impact of hydration on brain morphometric studies, blood plasma osmolality's effect on EPVS remains unexplored. This study investigated the influence of age, total intracranial volume (TIV), and blood plasma osmolality on EPVS characteristics in 59 healthy adults, each undergoing MRI and osmolality assessment twice within 14.8 months (mean ± 4 months). EPVS analysis was conducted in the centrum semiovale using high-resolution automated segmentation, followed by an optimization algorithm to enhance EPVS segmentation accuracy. Linear Mixed Effects model was used for the statistical analysis, which unveiled significant inter-individual variability in EPVS load and inter-hemispheric asymmetry. EPVS volume increased with age, higher TIV and lower blood plasma osmolality levels. Our findings offer valuable insights into EPVS characteristics among the healthy population, establishing a foundation to further explore age-related and pathological changes.
Centre for Genomic Regulation Barcelona Institute of Science and Technology Barcelona Spain
Centre of Scientific Information 3rd Faculty of Medicine Charles University Prague Czechia
Department of Anatomy 3rd Faculty of Medicine Charles University Prague Czechia
Citace poskytuje Crossref.org
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