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Genomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republic
K. Chudejova, T. Sourenian, J. Palkovicova, K. Stredanska, L. Nechutna, K. Vlkova, V. Studentova, Working Group for Monitoring of Antibiotic Resistance, J. Hrabak, CC. Papagiannitsis, M. Dolejska, I. Bitar, Working group for monitoring of...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
NU20J-05-00033
Agentura Pro Zdravotnický Výzkum České Republiky (AZV ČR)
NU22-09-00645
Agentura Pro Zdravotnický Výzkum České Republiky (AZV ČR)
LX22NPO5103
European Union-Next generation EU
NLK
Free Medical Journals
od 1972 do Před 6 měsíci
Freely Accessible Science Journals
od 1995 do Před 6 měsíci
PubMed Central
od 1972 do Před 1 rokem
Europe PubMed Central
od 1972 do Před 6 měsíci
Open Access Digital Library
od 1972-01-01
Open Access Digital Library
od 1972-01-01
PubMed
38624228
DOI
10.1128/aac.00133-24
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- beta-laktamasy * genetika MeSH
- biofilmy růst a vývoj MeSH
- epidemický výskyt choroby * MeSH
- Escherichia coli * genetika účinky léků izolace a purifikace enzymologie MeSH
- faktory virulence genetika MeSH
- fylogeneze MeSH
- genom bakteriální MeSH
- genomika metody MeSH
- infekce vyvolané Escherichia coli * mikrobiologie epidemiologie MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing Escherichia coli sequence type 38 (ST38) in the city of Brno. Forty-two ST38 E. coli isolates harbored the blaNDM-5 gene on the chromosome. Virulence factors confirmed the persistence of these isolates through biofilm formation. Single Nucleotide Polymorphisms (SNPs)-based phylogeny and CRISPR assay typing showed minimal genomic variations, implying a clonally driven outbreak. Results suggest that this high-risk clone may impose a nationwide problem.
Central European Institute of Technology University of Veterinary Sciences Brno Brno Czech Republic
Department of Microbiology University Hospital of Larissa Larissa Greece
Citace poskytuje Crossref.org
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