Production of alkaloids and differentiation in a submerged culture of Claviceps purpurea (Fr.) Tul
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
240760
DOI
10.1007/bf02876766
Knihovny.cz E-zdroje
- MeSH
- acetyl-CoA-karboxylasa metabolismus MeSH
- Claviceps enzymologie růst a vývoj metabolismus MeSH
- fermentace MeSH
- kyseliny ricinolejové biosyntéza MeSH
- mastné kyseliny biosyntéza MeSH
- námelové alkaloidy biosyntéza MeSH
- spory hub enzymologie růst a vývoj metabolismus MeSH
- tryptofan biosyntéza MeSH
- tryptofansynthasa metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetyl-CoA-karboxylasa MeSH
- kyseliny ricinolejové MeSH
- mastné kyseliny MeSH
- námelové alkaloidy MeSH
- tryptofan MeSH
- tryptofansynthasa MeSH
The submerged culture of the Claviceps purpurea strain studied was polymorphous. In the process of alkaloid synthesis, cytodifferentiation preceded biochemical differentiation. The onset of the alkaloid phase was characterized by: predominance of chlamydospores in the culture, the presence of vegetative cells with reduced or arrested proliferation, maximum acetylCoA carboxylase activity, the maximum amount of total fatty acids, an over-average cell pool tryptophan level and minimum tryptophan synthetase activity. Intracellular ricinoleic acid was an indicator of differentiation of the culture towards alkaloid formation and also of alkaloid synthesis. The cytodifferentiation period in the initial phases of fermentation, when the cell has several alternative possibilities of development, is regarded as the most sensitive sector of the regulatory mechanisms of alkaloid formation.
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