The effect of allopurinol on free oxygen radicals in myocardial reperfusion
Language English Country Czech Republic Media print
Document type Clinical Trial, Journal Article, Randomized Controlled Trial
PubMed
1339712
Knihovny.cz E-resources
- MeSH
- Allopurinol administration & dosage MeSH
- Administration, Oral MeSH
- Ventricular Function, Left drug effects MeSH
- Glutathione blood MeSH
- Isoenzymes MeSH
- Coronary Artery Bypass * MeSH
- Coronary Circulation drug effects MeSH
- Creatine Kinase blood MeSH
- Lactic Acid MeSH
- Lactates blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Malondialdehyde blood MeSH
- Premedication MeSH
- Reactive Oxygen Species metabolism MeSH
- Myocardial Reperfusion Injury drug therapy enzymology MeSH
- Free Radicals MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Allopurinol MeSH
- Glutathione MeSH
- Isoenzymes MeSH
- Creatine Kinase MeSH
- Lactic Acid MeSH
- Lactates MeSH
- Malondialdehyde MeSH
- Reactive Oxygen Species MeSH
- Free Radicals MeSH
The transmyocardial turnover of lactate, oxidized and reduced glutathione, malondialdehyde, and the isoenzyme CK-MB before and after restoration of myocardial blood flow was studied in 18 patients undergoing coronary artery surgery. Of this number, ten patients were given oral allopurinol preoperatively; the remaining patients made up the control group. Allopurinol significantly reduced the levels of free oxygen radicals. The enzymatic methods employed did not make it possible to evaluate the protective effect of allopurinol on reperfusion myocardial injury.
