The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A
Language English Country Switzerland Media print
Document type Journal Article
PubMed
1695467
DOI
10.1007/bf01969003
Knihovny.cz E-resources
- MeSH
- Adrenergic beta-Antagonists pharmacology MeSH
- Phosphatidylserines pharmacology MeSH
- Phospholipids metabolism MeSH
- Concanavalin A pharmacology MeSH
- Rats MeSH
- Arachidonic Acid MeSH
- Arachidonic Acids metabolism MeSH
- Mast Cells drug effects metabolism MeSH
- Membrane Lipids metabolism MeSH
- Prostaglandins biosynthesis MeSH
- Phosphorus Radioisotopes MeSH
- Calcium Radioisotopes MeSH
- In Vitro Techniques MeSH
- Thromboxane B2 biosynthesis MeSH
- Histamine Release drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adrenergic beta-Antagonists MeSH
- Phosphatidylserines MeSH
- Phospholipids MeSH
- Concanavalin A MeSH
- Arachidonic Acid MeSH
- Arachidonic Acids MeSH
- Membrane Lipids MeSH
- Prostaglandins MeSH
- Phosphorus Radioisotopes MeSH
- Calcium Radioisotopes MeSH
- Thromboxane B2 MeSH
Exaprolol, metipranolol and propranolol decreased significantly histamine liberation, degranulation, 45Ca uptake and thromboxane B2 formation in isolated rat mast cells stimulated with concanavalin A and phosphatidylserine. Moreover, exaprolol and metipranolol decreased 32P incorporation into membrane phospholipids and metipranolol and propranolol reduced the liberation of arachidonic acid from membrane phospholipids of stimulated mast cells. Exaprolol significantly increased the arachidonic acid liberation from these cells. Possible mechanisms of interaction of beta-adrenoceptor blocking drugs with isolated mast cells are discussed.
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