An alternative way of CD4 and CD8 association with protein kinases of the Src family
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
7806282
DOI
10.1007/bf00182321
Knihovny.cz E-resources
- MeSH
- CD4 Antigens analysis MeSH
- CD8 Antigens analysis MeSH
- Cell Membrane chemistry MeSH
- Glycosylphosphatidylinositols MeSH
- Humans MeSH
- Lymphocytes chemistry MeSH
- Neoplasm Proteins * MeSH
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck) MeSH
- Protein-Tyrosine Kinases analysis classification MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- CD4 Antigens MeSH
- CD8 Antigens MeSH
- FRK protein, human MeSH Browser
- Glycosylphosphatidylinositols MeSH
- Neoplasm Proteins * MeSH
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck) MeSH
- Protein-Tyrosine Kinases MeSH
The T-lymphocyte co-receptors of MHC glycoproteins CD4 and CD8 are known to be associated with the protein tyrosine kinase Lck via cysteine-containing sequences in the cytoplasmic domains of CD4 and CD8 and in the N-terminal domain of Lck. Here we demonstrate that a fraction of CD4 and CD8 molecules are associated with very large, detergent-resistant complexes containing several glycosylphosphatidylinositol-anchored proteins, (glyco)lipids, and protein tyrosine kinases Lck and Fyn but apparently no other major transmembrane proteins. Association of Lck and Fyn with these large complexes is, in contrast to simple CD4/CD8-Lck complexes, not sensitive to alkylation with iodoacetamide. These large complexes therefore represent an alternative way of association of CD4 and CD8 with the protein tyrosine kinases, which may play a role in signaling through these receptors.
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J Immunol. 1992 Oct 1;149(7):2262-70 PubMed
Mol Immunol. 1989 Feb;26(2):153-61 PubMed
Mol Cell Biol. 1990 May;10(5):1853-62 PubMed
Cell. 1990 Mar 9;60(5):755-65 PubMed
Cell. 1988 Oct 21;55(2):301-8 PubMed
Biochem Biophys Res Commun. 1994 Sep 15;203(2):1069-75 PubMed
Anal Biochem. 1989 Jul;180(1):72-8 PubMed
Scand J Clin Lab Invest Suppl. 1968;97:77-89 PubMed
Eur J Immunol. 1993 Oct;23 (10 ):2540-4 PubMed
Folia Biol (Praha). 1988;34(1):23-34 PubMed
J Immunol. 1991 Sep 1;147(5):1587-92 PubMed
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3611-5 PubMed
Eur J Immunol. 1992 Jan;22(1):283-6 PubMed
J Biol Chem. 1992 Jun 15;267(17):12317-22 PubMed
J Exp Med. 1993 Jul 1;178(1):245-55 PubMed
Biochemistry. 1993 Jun 29;32(25):6365-73 PubMed
Science. 1991 Nov 15;254(5034):1016-9 PubMed
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5190-4 PubMed
Folia Biol (Praha). 1986;32(1):12-25 PubMed
Immunol Today. 1991 Jan;12(1):35-41 PubMed
Eur J Immunol. 1993 Apr;23(4):825-31 PubMed
Nature. 1993 Aug 19;364(6439):729-32 PubMed
J Biol Chem. 1994 Jul 22;269(29):19123-7 PubMed
J Cell Biol. 1994 Jul;126(2):353-63 PubMed
J Cell Biol. 1993 Aug;122(4):789-807 PubMed
