- Publikační typ
- abstrakt z konference MeSH
- MeSH
- membránové mikrodomény imunologie MeSH
- receptory imunologické fyziologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- techniky in vitro MeSH
The presence of angiotensin II receptors was found on cells of three colorectal carcinoma cell lines. The binding assays with 125I-labelled angiotensin II and ligands specific for angiotensin AT1 or AT2 receptors showed that angiotensin receptors on colorectal cancer cells are mostly of the AT2 type. The binding capacity of tumor cells was not significantly changed by butyrate-induced differentiation.
- MeSH
- angiotensin II chemie metabolismus MeSH
- blokátory receptoru 1 pro angiotenzin II metabolismus MeSH
- buněčná membrána metabolismus MeSH
- financování organizované MeSH
- kolorektální nádory metabolismus MeSH
- lidé MeSH
- losartan metabolismus MeSH
- nádorové buněčné linie metabolismus MeSH
- oligopeptidy metabolismus MeSH
- radioizotopy jodu metabolismus MeSH
- receptor angiotensinu typ 2 genetika metabolismus MeSH
- Check Tag
- lidé MeSH
The previously developed mathematical model of CD4+ lymphocyte dynamics in HIV infection incorporated a homeostatic mechanism regulating production of both CD4+ and CD8+ lymphocytes. The model simulated the CD4+ lymphocyte dynamics well, but simulation of CD8+ lymphocyte values was not satisfactory, because simulated numbers of these cells increased even at later stages of infection, when no further increase was observed in infected individuals. Modifications of the model were attempted to obtain better simulation results assuming the influence of HIV infection on CD8+ lymphocyte maturation. Satisfactory results were obtained, if the influx of immature CD4+ and CD8+ lymphocytes was constrained by HIV infection. This modified version was then used for simulation of the anti-CD8 antibody administration effect in HIV-infected persons.
- MeSH
- CD8-pozitivní T-lymfocyty imunologie MeSH
- HIV infekce imunologie MeSH
- lidé MeSH
- matematické výpočty počítačové * MeSH
- modely imunologické * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
