Use of recombinant inbred strains for evaluation of intermediate phenotypes in spontaneous hypertension
Jazyk angličtina Země Austrálie Médium print
Typ dokumentu časopisecké články, přehledy
- MeSH
- fenotyp * MeSH
- hypertenze genetika MeSH
- krysa rodu Rattus MeSH
- modely nemocí na zvířatech MeSH
- potkani inbrední BN genetika MeSH
- potkani inbrední SHR genetika MeSH
- rekombinace genetická * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
1. The HXB/BXH recombinant inbred (RI) strains, derived from the spontaneously hypertensive rat (SHR) and the normotensive Brown Norway (BN.1x) rat, represent a very useful system for gene mapping and for genetic analysis of certain model diseases, such as spontaneous hypertension. 2. These RI strains were genotyped in multiple genetic polymorphisms and characterized in blood pressure and some intermediate phenotypes. 3. The analysis of RI strains has revealed that (i) a gene in the vicinity of the major histocompatibility complex (RT1) on chromosome 20, a kallikrein-related gene on chromosome 4 and the renin gene on chromosome 13 were significantly associated with blood pressure, and (ii) Na+ leak in red blood cells correlated with blood pressure whereas relative heart and kidney weights as well as platelet aggregation did not.
Citace poskytuje Crossref.org
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