Imipramine distribution among red blood cells, plasma and brain tissue
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8902557
Knihovny.cz E-zdroje
- MeSH
- antidepresiva tricyklická aplikace a dávkování krev farmakokinetika MeSH
- cytosol metabolismus MeSH
- desipramin krev farmakokinetika MeSH
- erytrocytární membrána metabolismus MeSH
- erytrocyty metabolismus MeSH
- imipramin aplikace a dávkování krev farmakokinetika MeSH
- krysa rodu Rattus MeSH
- membrány metabolismus MeSH
- mozek metabolismus MeSH
- potkani Wistar MeSH
- radioimunoanalýza MeSH
- tkáňová distribuce MeSH
- tritium MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antidepresiva tricyklická MeSH
- desipramin MeSH
- imipramin MeSH
- tritium MeSH
The relations between the concentrations of a drug in the blood (plasma, haemoglobin, red blood cells (RBCs), RBC membranes) and in the brain tissue (homogenate, membranes, cytosol) were investigated during chronic administration of imipramine. Radioimmunoassay was employed to measure the antidepressant concentrations. The concentrations were measured and analysed in 40 rats receiving various doses of imipramine. The concentration of total imipramine (imipramine + desipramine) in erythrocyte membranes (ghosts) amounted to 79.4 +/- 4.6% (mean +/- S.E.M., N = 40) of those measured in intact RBCs. Marked accumulation of the drug in the brain tissue, especially in brain cell membranes, was confirmed. The concentrations in brain tissue homogenate was found to be 14.8 times higher than that in RBCs. Values in brain membranes were 10.9 times higher than that in blood element membranes. There is a significant association between the concentrations measured in brain homogenate, the blood plasma and RBC membranes. Blood concentrations can be used to estimate imipramine concentrations in the brain.
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