The assumption that hippocampal place cells (PCs) form the neural substrate of cognitive maps can be experimentally tested by comparing the effect of experimental interventions on PC activity and place navigation. Conditions that interfere with place navigation (darkness, cholinergic blockade) but leave PC activity unaffected obviously disrupt spatial memory at a post-PC level. Situations creating a conflict between egocentric and allocentric orientation (place navigation in the Morris water maze filled with slowly rotating water) slow down spatial learning. PC recording in rats searching food pellets in a rotating arena makes it possible to determine which firing fields are stable relative to the room (allocentrically dependent on sighted extramaze landmarks), to the surface of the arena (dependent on egocentric path integration mechanisms and intra-arena cues), or disappear during rotation. Such comparison is made possible by the computerized tracking system simultaneously displaying a rat's locomotion and the respective firing rate maps both in the room reference and arena reference frames. More severe conflict between allocentric and egocentric inputs is produced in the field clamp situation when the rat searching food in a ring-shaped arena is always returned by rotation of the arena to the same allocentric position. Ten-minute exposure to this condition caused subsequent disintegration or remapping of 70% PCs (n = 100). Simultaneous examination of PC activity and navigation is possible in the place avoidance task. A rat searching food in a stationary or rotating arena learns to avoid an allocentrically or egocentrically defined location where it receives mild electric footshock. In the place preference task the rat releases pellet delivery by entering an unmarked goal area and staying in it for a criterion time. Both tasks allow direct comparison of the spatial reference frames used by the PCs and by the behaving animal.

Institute of Physiology Academy of Sciences of the Czech Republic Prague

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Leao A A P. J Neurophysiol. 1944;7:359–390.

Buresova O. Physiol Bohemoslov. 1956;5:350–358. PubMed

Bures J, Buresova O, Krivanek J. The Mechanism and Applications of Leao’s Spreading Depression of EEG Activity. New York: Academic; 1974.

Bures J, Buresova O, Huston J P. Techniques and Basic Experiments for the Study of Brain and Behavior. Amsterdam: Elsevier; 1976.

Bures J, Buresova O, Krivanek J. Brain and Behavior: Paradigms for Research in Neural Mechanisms. Chichester, U.K.: Wiley; 1988.

Dolbakyan E, Hernandez-Mesa N, Bures J. Neuroscience. 1977;2:73–80. PubMed

Aleksanyan Z A, Buresova O, Bures J. Physiol Behav. 1976;17:173–179. PubMed

Buresova O. Acta Neurobiol Exp. 1980;40:51–66. PubMed

Olton D S, Samuelson R J. J Exp Psychol Anim Behav Processes. 1976;2:97–116.

Morris R G M. Learn Motiv. 1981;12:239–261.

Squire L R. Memory and Brain. Oxford: Oxford Univ. Press; 1987.

Brandeis R, Brandys Y, Yehuda S. Int J Neurosci. 1989;48:29–69. PubMed

Bures J, Buresova O. In: Machinery of Mind. John E R, editor. Boston: Birkhauser; 1990. pp. 291–310.

Buresova O, Krekule I, Zahalka A, Bures J. J Neurosci Methods. 1985;15:63–72. PubMed

Morris R G M. J Neurosci Methods. 1984;14:47–60. PubMed

Spooner R J W, Thompson A, Hall J, Morris R G M, Salter S H. Learn Mem. 1994;1:203–211. PubMed

Buresova O, Homuta L, Krekule I, Bures J. Behav Neural Biol. 1988;49:240–248. PubMed

O’Keefe J, Nadel L. The Hippocampus as a Cognitive Map. Oxford: Oxford Univ. Press; 1978.

Gallistel C R. The Organization of Learning. Cambridge, MA: MIT Press; 1990.

Tolman E C. Psychol Rev. 1948;55:189–208. PubMed

Alyan S, Jander R. Anim Behav. 1994;48:285–298.

Jarrard R D. Behav Neural Biol. 1993;60:9–26. PubMed

Morris R G M, Garrud P, Rawlins J N P, O’Keefe J. Nature (London) 1982;297:681–683. PubMed

Fenton A A, Bures J. Behav Neurosci. 1993;107:552–563. PubMed

Whishaw I Q, Cassel J-C, Jarrard L E. J Neurosci. 1995;15:5779–5788. PubMed PMC

Kelsey J E, Vargas H. Behav Neurosci. 1988;102:289–293. PubMed

Schenk F, Morris R G M. Exp Brain Res. 1985;58:11–28. PubMed

Moser M-B, Moser E I, Forrest E, Andersen P. Proc Natl Acad Sci USA. 1995;92:9697–9701. PubMed PMC

Kolb B, Sutherland R J, Whishaw I Q. J Comp Physiol Psychol. 1983;97:13–27.

Mizumori S J Y, Miya D Y, Ward K E. Brain Res. 1994;644:168–174. PubMed

Whishaw I Q, Mittleman G, Bunch S T, Dunnett S B. Behav Brain Res. 1987;24:125–138. PubMed

O’Keefe J, Dostrovsky J. Brain Res. 1971;34:171–175. PubMed

Ranck J B., Jr Exp Neurol. 1973;41:461–531. PubMed

Fox S E, Ranck J B., Jr Exp Neurol. 1975;49:299–313. PubMed

O’Keefe J, Conway D H. Exp Brain Res. 1978;31:573–590. PubMed

Kubie J L, Muller R U, Hawley E S, Jia C P. Soc Neurosci Abstr. 1992;18:1062.

Markus E J, Barnes C A, McNaughton B L, Gladden V L, Skaggs W E. Hippocampus. 1994;4:410–421. PubMed

Knierim J J, Kudrimoti H S, McNaughton B L. J Neurosci. 1995;15:1648–1659. PubMed PMC

Quirk G J, Muller R U, Kubie J L. J Neurosci. 1990;10:2008–2017. PubMed PMC

Miniaci M C, Moghaddam M, Bures J. Soc Neurosci Abstr. 1996;22:914.

Muller R U, Stead M, Pach J. J Gen Physiol. 1996;107:663–694. PubMed PMC

Muller R U, Kubie J L, Ranck J B., Jr J Neurosci. 1987;7:1935–1950. PubMed PMC

Muller R U, Kubie J L. J Neurosci. 1989;9:4101–4110. PubMed PMC

Sutherland R J, Dyck R H. Can J Psychol. 1984;38:322–347.

Moghaddam M, Bures J. Behav Brain Res. 1996;78:121–129. PubMed

Save E, Moghaddam M. Behav Neurosci. 1996;110:74–85. PubMed

O’Keefe J. Exp Neurol. 1976;51:78–109. PubMed

Hill A J, Best P J. Exp Neurol. 1981;74:204–217. PubMed

McNaughton B L, Leonard B, Chen L. Psychobiology. 1989;17:230–235.

Markus E J, Qin Y-L, Leonard B, Skaggs W E, McNaughton B L, Barnes C. J Neurosci. 1995;15:7079–7094. PubMed PMC

Arolfo M P, Nerad L, Schenk F, Bures J. Behav Neurosci. 1994;108:308–316. PubMed

Rashidy-Pour A, Zinyuk L, Kaminsky Yu, Bures J. Eur J Neurosci. 1995;S8:185. (abstr.).

Muller R U, Kubie J L. J Neurosci. 1987;7:1951–1968. PubMed PMC

Buresova O, Bolhuis J J, Bures J. Behav Neurosci. 1986;100:476–482. PubMed

Mizumori S J Y, McNaughton B L, Barnes C A, Fox K B. J Neurosci. 1989;9:3915–3928. PubMed PMC

Brazhnik E, Muller R U, Fox S E. Soc Neurosci Abstr. 1995;21:1439.

Moghaddam M, Bures J. Soc Neurosci Abstr. 1994;20:804.

Zinyuk L, Kaminsky Yu, Kubik S, Bures J. Eur J Neurosci. 1996;S9:140. (abstr.).

O’Keefe J, Speakman A. Exp Brain Res. 1987;68:1–27. PubMed

Sharp P E, Muller R U, Kubie J L. J Neurosci. 1990;10:3093–3105. PubMed PMC

Taube J. J Neurosci. 1995;15:70–86. PubMed PMC

Rotenberg A, Kubie J L, Muller R U. Soc Neurosci Abstr. 1993;19:357.

Gothard K M, Skaggs W E, Moore K M, McNaughton B L. J Neurosci. 1996;16:823–835. PubMed PMC

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