Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats
Jazyk angličtina Země Irsko Médium print
Typ dokumentu časopisecké články
PubMed
9020515
DOI
10.1016/s0300-483x(96)03537-8
PII: S0300-483X(96)03537-8
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa krev metabolismus MeSH
- antidota farmakologie MeSH
- atropin farmakologie MeSH
- benaktyzin farmakologie MeSH
- biperiden farmakologie MeSH
- bránice enzymologie MeSH
- cholinesterasové inhibitory farmakologie toxicita MeSH
- fyziologický stres chemicky indukované MeSH
- játra účinky léků enzymologie MeSH
- kortikosteron krev MeSH
- krysa rodu Rattus MeSH
- lékové interakce MeSH
- mozek enzymologie MeSH
- oximy MeSH
- potkani Wistar MeSH
- pyridinové sloučeniny farmakologie MeSH
- reaktivátory cholinesterázy farmakologie MeSH
- soman toxicita MeSH
- tyrosinaminotransferasa metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- antidota MeSH
- asoxime chloride MeSH Prohlížeč
- atropin MeSH
- benaktyzin MeSH
- biperiden MeSH
- cholinesterasové inhibitory MeSH
- kortikosteron MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterázy MeSH
- soman MeSH
- tyrosinaminotransferasa MeSH
The influence of cholinolytic drugs (atropine, benactyzine, biperiden) on the efficacy of the oxime HI-6 (1-[[[(4-aminocarbonyl)pyridinio]methoxy ]methyl]-2-[hydroxyimino)methyl]pyridinium dichloride monohydrate) on soman-induced anticholinesterase and stressogenic effects was studied in rats. Soman-induced acetylcholinesterase inhibition in blood and diaphragm and the stressogenic effects of soman, i.e. an increase in plasma corticosterone level and liver tyrosine aminotransferase activity, were more significantly diminished by HI-6 in combination with benactyzine or biperiden in comparison with HI-6 plus atropine. These findings support a hypothesis that benactyzine as well as biperiden can increase the efficacy of the oxime HI-6 in comparison with atropine. They demonstrate the importance of cholinolytic drug selection in the treatment of soman poisoning in rats. Ltd.
Citace poskytuje Crossref.org
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