Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats
Language English Country Ireland Media print
Document type Journal Article
PubMed
9020515
DOI
10.1016/s0300-483x(96)03537-8
PII: S0300-483X(96)03537-8
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase blood metabolism MeSH
- Antidotes pharmacology MeSH
- Atropine pharmacology MeSH
- Benactyzine pharmacology MeSH
- Biperiden pharmacology MeSH
- Diaphragm enzymology MeSH
- Cholinesterase Inhibitors pharmacology toxicity MeSH
- Stress, Physiological chemically induced MeSH
- Liver drug effects enzymology MeSH
- Corticosterone blood MeSH
- Rats MeSH
- Drug Interactions MeSH
- Brain enzymology MeSH
- Oximes MeSH
- Rats, Wistar MeSH
- Pyridinium Compounds pharmacology MeSH
- Cholinesterase Reactivators pharmacology MeSH
- Soman toxicity MeSH
- Tyrosine Transaminase metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Antidotes MeSH
- asoxime chloride MeSH Browser
- Atropine MeSH
- Benactyzine MeSH
- Biperiden MeSH
- Cholinesterase Inhibitors MeSH
- Corticosterone MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- Soman MeSH
- Tyrosine Transaminase MeSH
The influence of cholinolytic drugs (atropine, benactyzine, biperiden) on the efficacy of the oxime HI-6 (1-[[[(4-aminocarbonyl)pyridinio]methoxy ]methyl]-2-[hydroxyimino)methyl]pyridinium dichloride monohydrate) on soman-induced anticholinesterase and stressogenic effects was studied in rats. Soman-induced acetylcholinesterase inhibition in blood and diaphragm and the stressogenic effects of soman, i.e. an increase in plasma corticosterone level and liver tyrosine aminotransferase activity, were more significantly diminished by HI-6 in combination with benactyzine or biperiden in comparison with HI-6 plus atropine. These findings support a hypothesis that benactyzine as well as biperiden can increase the efficacy of the oxime HI-6 in comparison with atropine. They demonstrate the importance of cholinolytic drug selection in the treatment of soman poisoning in rats. Ltd.
References provided by Crossref.org
Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase
