Hereditary melanoblastoma in miniature pigs and its successful therapy by devitalization technique
Language English Country France Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10644016
Knihovny.cz E-resources
- MeSH
- Antigens, Neoplasm analysis immunology MeSH
- Hair Color genetics MeSH
- Breeding MeSH
- Neoplastic Syndromes, Hereditary genetics immunology pathology MeSH
- Genes, Dominant MeSH
- Phenotype MeSH
- Genes, Recessive MeSH
- Major Histocompatibility Complex genetics MeSH
- Ligation MeSH
- Melanocytes immunology MeSH
- Melanoma, Experimental blood supply congenital genetics immunology pathology surgery MeSH
- Neoplasm Metastasis MeSH
- Swine, Miniature genetics MeSH
- Neoplastic Stem Cells pathology MeSH
- Skin Neoplasms blood supply congenital genetics pathology surgery MeSH
- Lung Neoplasms blood supply congenital genetics pathology surgery MeSH
- Splenic Neoplasms blood supply congenital genetics pathology surgery MeSH
- Skin Pigmentation genetics MeSH
- Nevus, Pigmented congenital genetics pathology MeSH
- Swine MeSH
- Suture Techniques MeSH
- Remission, Spontaneous MeSH
- Viscera pathology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Neoplasm MeSH
Applying selective breeding for 10 years we established the MeLiM (Melanoblastoma-bearing Libechov Minipigs) strain. Melanoblastoma (MB) in this strain shows a hereditary occurrence. Cutaneous tumours are usually nodular, multiple and distributed on various parts of body. They appear in darkly pigmented animals already at the birth or during two months thereafter (57% of all animals). Numerous organ metastases mainly into the spleen, lymph nodes and lungs are regularly ascertained in animals with cutaneous MB. Tumour cells were surprisingly found also in the inner organs of phenotypically healthy minipigs in which no cutaneous MBs were observed visually (27% of all animals). About 34% of all affected piglets die during the first 2 months of age. These features document a malignancy of this tumour in the MeLiM strain. Original surgical technique was applied in more than 40 affected minipigs at 1-2 months of age. It consists in a devitalization (ischemization) of one of cutaneous tumours by the mattress sutures conducted around the tumour base without any excision of tumour tissue. This simple procedure causes a total destruction of MB cells in all cutaneous tumours as well as in all organ metastases during 4-6 months. Animals treated by this technique were fully healed of tumour cells and no relapses were observed. This technique could bring similar positive results also in therapy of human MB.
Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
Tumour devascularisation as a potential immunotherapeutic strategy
