Effect of hyperammonemia on leucine and protein metabolism in rats

. 2000 Oct ; 49 (10) : 1330-4.

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid11079824
Odkazy

PubMed 11079824
DOI 10.1053/meta.2000.9531
PII: S0026-0495(00)10873-X
Knihovny.cz E-zdroje

The cause of muscle wasting and decreased plasma levels of branched chain amino acids (BCAA), valine, leucine, and isoleucine in liver cirrhosis is obscure. Here we have evaluated the effect of hyperammonemia. Rats were infused with either an ammonium acetate/bicarbonate mixture, a sodium acetate/bicarbonate mixture, or saline for 320 minutes. The parameters of leucine and protein metabolism were evaluated in the whole body and in several tissues using a primed constant intravenous infusion of L-[1-14C]leucine. Ammonium infusion caused an increase in ammonia and glutamine levels in plasma, a decrease in BCAA and alanine in plasma and skeletal muscle, a significant decrease in whole-body proteolysis and protein synthesis, and an increase in leucine oxidized fraction. A significant decrease in protein synthesis after ammonium infusion was observed in skeletal muscle while a nonsignificant effect was observed in liver, gut, heart, spleen, and kidneys. We conclude that the decrease in plasma BCAA after ammonia infusion is associated with decreased proteolysis and increased leucine oxidized fraction.

Citace poskytuje Crossref.org

Nejnovějších 20 citací...

Zobrazit více v
Medvik | PubMed

Origin and Roles of Alanine and Glutamine in Gluconeogenesis in the Liver, Kidneys, and Small Intestine under Physiological and Pathological Conditions

. 2024 Jun 27 ; 25 (13) : . [epub] 20240627

Aspartic Acid in Health and Disease

. 2023 Sep 17 ; 15 (18) : . [epub] 20230917

Muscle Amino Acid and Adenine Nucleotide Metabolism during Exercise and in Liver Cirrhosis: Speculations on How to Reduce the Harmful Effects of Ammonia

. 2022 Oct 13 ; 12 (10) : . [epub] 20221013

The role of skeletal muscle in the pathogenesis of altered concentrations of branched-chain amino acids (valine, leucine, and isoleucine) in liver cirrhosis, diabetes, and other diseases

. 2021 Jul 12 ; 70 (3) : 293-305. [epub] 20210512

Branched-Chain Amino Acids and Branched-Chain Keto Acids in Hyperammonemic States: Metabolism and as Supplements

. 2020 Aug 09 ; 10 (8) : . [epub] 20200809

Effects of histidine supplementation on amino acid metabolism in rats

. 2020 Feb 19 ; 69 (1) : 99-111. [epub] 20191219

Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis

. 2018 Dec ; 99 (6) : 274-281. [epub] 20190113

Effects of branched-chain amino acids on muscles under hyperammonemic conditions

. 2018 Nov ; 74 (4) : 523-530. [epub] 20180730

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

. 2018 ; 15 () : 33. [epub] 20180503

Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives

. 2014 Mar ; 29 (1) : 9-17. [epub] 20130831

Muscle wasting in animal models of severe illness

. 2012 Jun ; 93 (3) : 157-71. [epub] 20120508

Najít záznam

Citační ukazatele

Nahrávání dat ...

    Možnosti archivace