Risk of cancer in an occupationally exposed cohort with increased level of chromosomal aberrations
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
11171523
PubMed Central
PMC1242049
DOI
10.1289/ehp.0110941
PII: sc271_5_1835
Knihovny.cz E-resources
- MeSH
- Chromosome Aberrations * MeSH
- Chromosome Disorders * MeSH
- Cytogenetics MeSH
- Adult MeSH
- Risk Assessment MeSH
- Incidence MeSH
- Carcinogens, Environmental adverse effects MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasms epidemiology etiology genetics MeSH
- Occupational Exposure * MeSH
- Radon adverse effects MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Names of Substances
- Carcinogens, Environmental MeSH
- Radon MeSH
We used cytogenetic analysis to carry out a cohort study in which the major objective was to test the association between frequency of chromosomal aberrations and subsequent risk of cancer. In spite of the extensive use of the cytogenetic analysis of human peripheral blood lymphocytes in biomonitoring of exposure to various mutagens and carcinogens on an ecologic level, the long-term effects of an increased frequency of chromosomal aberrations in individuals are still uncertain. Few epidemiologic studies have addressed this issue, and a moderate risk of cancer in individuals with an elevated frequency of chromosomal aberrations has been observed. In the present study, we analyzed data on 8,962 cytogenetic tests and 3,973 subjects. We found a significant and strong association between the frequency of chromosomal aberrations and cancer incidence in a group of miners exposed to radon, where a 1% increase in frequency of chromosomal aberrations was followed by a 64% increase in risk of cancer (p < 0.000). In contrast, the collected data are inadequate for a critical evaluation of the association with exposure to other chemicals.
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Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer
