Risk of cancer in an occupationally exposed cohort with increased level of chromosomal aberrations
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.
PubMed
11171523
PubMed Central
PMC1242049
DOI
10.1289/ehp.0110941
PII: sc271_5_1835
Knihovny.cz E-zdroje
- MeSH
- chromozomální aberace * MeSH
- chromozomální poruchy * MeSH
- cytogenetika MeSH
- dospělí MeSH
- hodnocení rizik MeSH
- incidence MeSH
- karcinogeny životního prostředí škodlivé účinky MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory epidemiologie etiologie genetika MeSH
- pracovní expozice * MeSH
- radon škodlivé účinky MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Názvy látek
- karcinogeny životního prostředí MeSH
- radon MeSH
We used cytogenetic analysis to carry out a cohort study in which the major objective was to test the association between frequency of chromosomal aberrations and subsequent risk of cancer. In spite of the extensive use of the cytogenetic analysis of human peripheral blood lymphocytes in biomonitoring of exposure to various mutagens and carcinogens on an ecologic level, the long-term effects of an increased frequency of chromosomal aberrations in individuals are still uncertain. Few epidemiologic studies have addressed this issue, and a moderate risk of cancer in individuals with an elevated frequency of chromosomal aberrations has been observed. In the present study, we analyzed data on 8,962 cytogenetic tests and 3,973 subjects. We found a significant and strong association between the frequency of chromosomal aberrations and cancer incidence in a group of miners exposed to radon, where a 1% increase in frequency of chromosomal aberrations was followed by a 64% increase in risk of cancer (p < 0.000). In contrast, the collected data are inadequate for a critical evaluation of the association with exposure to other chemicals.
Zobrazit více v PubMed
Mutat Res. 1985 Dec;144(4):277-80 PubMed
Mutat Res. 1985 Dec;144(4):271-5 PubMed
IARC Sci Publ. 1992;(116):543-54 PubMed
Cancer Res. 1994 Jun 1;54(11):2919-22 PubMed
Radiat Res. 1994 Jul;139(1):40-6 PubMed
Cancer Genet Cytogenet. 1995 Feb;79(2):133-5 PubMed
Cent Eur J Public Health. 1995 Nov;3(4):219-23 PubMed
Med Lav. 1998 Mar-Apr;89(2):124-31 PubMed
Cancer Res. 1998 Sep 15;58(18):4117-21 PubMed
Toxicol Lett. 1998 Aug;96-97:137-42 PubMed
Cancer Res. 1999 Apr 1;59(7):1481-4 PubMed
Cancer Res. 2000 Mar 15;60(6):1619-25 PubMed
Mutat Res. 1977 Jul;48(3-4):355-60 PubMed
Arch Toxicol Suppl. 1980;4:11-8 PubMed
Mutat Res. 1983 Oct;122(1):59-64 PubMed
J Hyg Epidemiol Microbiol Immunol. 1983;27(3):305-18 PubMed
Cancer Genet Cytogenet. 1990 Mar;45(1):85-92 PubMed
Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer
