Novel oxindole derivatives and their biological activity
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11702401
DOI
10.1007/bf02818531
Knihovny.cz E-resources
- MeSH
- Antifungal Agents pharmacology MeSH
- Aspergillus flavus drug effects MeSH
- Botrytis drug effects MeSH
- Fusarium drug effects MeSH
- Indoles metabolism pharmacology MeSH
- Microsporum drug effects MeSH
- Microbial Sensitivity Tests MeSH
- Oxidation-Reduction MeSH
- Penicillium metabolism MeSH
- Antineoplastic Agents pharmacology MeSH
- Rhizopus drug effects MeSH
- Mutagenicity Tests MeSH
- Trichophyton drug effects MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Indoles MeSH
- Antineoplastic Agents MeSH
The antifungal activity of fourteen novel derivatives of oxindole with side chain was studied using representatives of toxinogenic, phytopathogenic and dermatophytic filamentous fungi. Derivatives with exocyclic C=C bond in position C-3 exhibited a higher antifungal activity compared with derivatives with an exocyclic C-C bond in the same position. The strongest antifungal effects were shown by 3-(-2-thienoylmethylidene)-indol-2(3H)-ones.
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