Particulate 1,3-beta-D-glucan, carboxymethylglucan and sulfoethylglucan--influence of their oral or intraperitoneal administration on immunological respondence of mice
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
11898349
DOI
10.1007/bf02818003
Knihovny.cz E-resources
- MeSH
- Enzyme Activation drug effects MeSH
- Administration, Oral MeSH
- beta-Glucans * MeSH
- Cell Division MeSH
- Glucans pharmacology MeSH
- Injections, Intraperitoneal MeSH
- Cells, Cultured MeSH
- Lipopolysaccharides MeSH
- Mice, Inbred BALB C MeSH
- Mice immunology MeSH
- Nitric Oxide biosynthesis MeSH
- Macrophages, Peritoneal drug effects physiology MeSH
- Peroxidase metabolism MeSH
- Saccharomyces cerevisiae MeSH
- Spleen drug effects pathology MeSH
- Body Weight drug effects MeSH
- Organ Size drug effects MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice immunology MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- beta-1,3-glucan MeSH Browser
- beta-Glucans * MeSH
- Glucans MeSH
- Lipopolysaccharides MeSH
- Nitric Oxide MeSH
- Peroxidase MeSH
The effect of orally or intraperitoneally administered particulate 1,3-beta-D-glucan (PBG), carboxymethylglucan (CMG) or sulfoethylglucan (SEG), obtained from the culture filtrate of Saccharomyces cerevisiae, on the functions of murine peritoneal adherent cells (PC) (peroxidase activity, nitric oxide synthesis), on relative organ mass and on proliferation of splenocytes was determined. The modulating activities after parenteral and non-parenteral administration of these polysaccharides were compared. Significant enhancement of NO production was observed only after in vitro cultivation of PC in the presence of lipopolysaccharide (LPS) in groups of mice treated repeatedly orally with CMG, PBG and SEG at a dose of 50 mg/kg body mass. Peroxidase activity increased significantly after repeated oral administration of CMG and PBG at doses 150 and 50 mg/kg, SEG 150 mg/kg body mass. The peroxidase activity and NO synthesis in mice given a single intraperitoneal injection of glucans (15 mg/kg body mass) were slightly higher than those after oral administration. Neither a significant enhancement of relative organ mass nor enhancement of the proliferative response of splenocytes to in vitro added stimuli (LPS, phytohemagglutinin) after repeated oral or single intraperitoneal administration of beta-glucans was observed.
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