Particulate 1,3-beta-D-glucan, carboxymethylglucan and sulfoethylglucan--influence of their oral or intraperitoneal administration on immunological respondence of mice
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
11898349
DOI
10.1007/bf02818003
Knihovny.cz E-zdroje
- MeSH
- aktivace enzymů účinky léků MeSH
- aplikace orální MeSH
- beta-glukany * MeSH
- buněčné dělení MeSH
- glukany farmakologie MeSH
- injekce intraperitoneální MeSH
- kultivované buňky MeSH
- lipopolysacharidy MeSH
- myši inbrední BALB C MeSH
- myši imunologie MeSH
- oxid dusnatý biosyntéza MeSH
- peritoneální makrofágy účinky léků fyziologie MeSH
- peroxidasa metabolismus MeSH
- Saccharomyces cerevisiae MeSH
- slezina účinky léků patologie MeSH
- tělesná hmotnost účinky léků MeSH
- velikost orgánu účinky léků MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši imunologie MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- beta-1,3-glucan MeSH Prohlížeč
- beta-glukany * MeSH
- glukany MeSH
- lipopolysacharidy MeSH
- oxid dusnatý MeSH
- peroxidasa MeSH
The effect of orally or intraperitoneally administered particulate 1,3-beta-D-glucan (PBG), carboxymethylglucan (CMG) or sulfoethylglucan (SEG), obtained from the culture filtrate of Saccharomyces cerevisiae, on the functions of murine peritoneal adherent cells (PC) (peroxidase activity, nitric oxide synthesis), on relative organ mass and on proliferation of splenocytes was determined. The modulating activities after parenteral and non-parenteral administration of these polysaccharides were compared. Significant enhancement of NO production was observed only after in vitro cultivation of PC in the presence of lipopolysaccharide (LPS) in groups of mice treated repeatedly orally with CMG, PBG and SEG at a dose of 50 mg/kg body mass. Peroxidase activity increased significantly after repeated oral administration of CMG and PBG at doses 150 and 50 mg/kg, SEG 150 mg/kg body mass. The peroxidase activity and NO synthesis in mice given a single intraperitoneal injection of glucans (15 mg/kg body mass) were slightly higher than those after oral administration. Neither a significant enhancement of relative organ mass nor enhancement of the proliferative response of splenocytes to in vitro added stimuli (LPS, phytohemagglutinin) after repeated oral or single intraperitoneal administration of beta-glucans was observed.
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Cesk Farm. 1993 Aug;42(4):184-7 PubMed
Folia Microbiol (Praha). 2000;45(5):457-63 PubMed
Int J Immunopharmacol. 1989;11(7):761-9 PubMed
J Leukoc Biol. 1991 Apr;49(4):342-51 PubMed
J Clin Invest. 1996 Jul 1;98(1):50-61 PubMed
Vet Microbiol. 1988 Jan;16(1):67-76 PubMed
J Leukoc Biol. 1993 Dec;54(6):564-71 PubMed
J Med Microbiol. 1987 Jun;23(4):363-5 PubMed
Biochem Biophys Res Commun. 1998 Mar 6;244(1):115-9 PubMed
Immunol Lett. 1996 Nov;53(2-3):157-63 PubMed
Folia Microbiol (Praha). 2001;46(4):353-8 PubMed
Hepatology. 1998 May;27(5):1241-8 PubMed
Environ Toxicol Pharmacol. 1998 Jun 2;5(4):273-81 PubMed
Int J Immunopharmacol. 1990;12(6):675-84 PubMed
Epidemiol Mikrobiol Imunol. 1998 Aug;47(3):103-20 PubMed
Carbohydr Res. 1994 Oct 3;263(1):111-21 PubMed
J Leukoc Biol. 1996 Jul;60(1):118-24 PubMed
Kinetics of soluble glucan production by Claviceps viridis
