Body weight in mouse embryos specifies staging of tooth development
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Embryo, Mammalian anatomy & histology physiology MeSH
- Embryonic and Fetal Development MeSH
- Mice, Inbred ICR MeSH
- Mice embryology MeSH
- Odontoblasts cytology MeSH
- Odontogenesis physiology MeSH
- Body Weight * MeSH
- Animals MeSH
- Check Tag
- Mice embryology MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Great intra- and interlitter variation in morphological stages is known to exist among mouse embryos of the same strain at a similar chronological stage. With the aim of searching for an easily measurable parameter that correlates well with tooth development, the morpho- and histodifferentiation of teeth were compared in embryos classified according to the embryonic day (ED) specified by wet body weight. The embryos and fetuses were harvested at 12-h intervals from ED12.5 until birth, weighed, fixed, and processed histologically. The tooth age was determined according to the developmental progress of the first molar, evaluated based on morpho- and histodifferentiation criteria. The data documented a better correlation between tooth morpho-histodifferentiation with the age/weight staging than with only the embryonic day. The cyto-differentiation of odontoblasts exhibited a high interlitter variability and was similar within specimens of the same litter, regardless of their body weight differences.
References provided by Crossref.org
Eda controls the size of the enamel knot during incisor development
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