Great intra- and interlitter variation in morphological stages is known to exist among mouse embryos of the same strain at a similar chronological stage. With the aim of searching for an easily measurable parameter that correlates well with tooth development, the morpho- and histodifferentiation of teeth were compared in embryos classified according to the embryonic day (ED) specified by wet body weight. The embryos and fetuses were harvested at 12-h intervals from ED12.5 until birth, weighed, fixed, and processed histologically. The tooth age was determined according to the developmental progress of the first molar, evaluated based on morpho- and histodifferentiation criteria. The data documented a better correlation between tooth morpho-histodifferentiation with the age/weight staging than with only the embryonic day. The cyto-differentiation of odontoblasts exhibited a high interlitter variability and was similar within specimens of the same litter, regardless of their body weight differences.

Institute of Experimental Medicine Academy of Sciences of the Czech Republic Videnska 1083 142 20 Prague 4 Czech Republic

Citace poskytuje Crossref.org

Sprouty2/4 deficiency disrupts early signaling centers impacting chondrogenesis in the mouse forelimb

Eda controls the size of the enamel knot during incisor development

Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

Developmental variability channels mouse molar evolution

Specification of Sprouty2 functions in osteogenesis in in vivo context

Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning

FGF signaling refines Wnt gradients to regulate the patterning of taste papillae

Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology

One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule

Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation

Three-dimensional analysis of the early development of the dentition

Patterning by heritage in mouse molar row development

Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis