Oldies but goldies: searching for Christmas trees within the nucleolar architecture
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
14507479
DOI
10.1016/j.tcb.2003.08.003
PII: S0962892403001946
Knihovny.cz E-resources
- MeSH
- Cell Nucleolus genetics ultrastructure MeSH
- Microscopy, Electron MeSH
- In Situ Hybridization MeSH
- Immunohistochemistry MeSH
- Humans MeSH
- Ribosomes ultrastructure MeSH
- RNA, Ribosomal ultrastructure MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- RNA, Ribosomal MeSH
The nucleolus is the prominent nuclear organelle in which the biogenesis of ribosomal RNA and ribosomes takes place. Understanding of the molecular processes in the nucleolus is rapidly expanding; however, opinions and results on the precise localization of active ribosomal genes - in either of two nucleolar subcompartments, fibrillar centers and dense fibrillar components - are still divided. This review discusses the difficulties in studying the nucleolar structure using microscopy, and provides an overview of the published data, critically examining their relevance to the controversy. Additionally, evidence showing that the dense fibrillar components encompass the Christmas tree structures is discussed and ways to reconcile the controversy are proposed.
References provided by Crossref.org
Fluctuations of pol I and fibrillarin contents of the nucleoli
Reproduction of the FC/DFC units in nucleoli
Nucleolar DNA: the host and the guests
Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments
Pontin is localized in nucleolar fibrillar centers
Asymmetrical distribution of the transcriptionally competent NORs in mitosis
Positioning of the NOR-bearing chromosomes in relation to nucleoli in daughter cells after mitosis
