Changes in cholesterol and its precursors during the first days after major trauma
Language English Country Austria Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
14743581
DOI
10.1007/bf03040502
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Time Factors MeSH
- Cholesterol blood MeSH
- Chromatography, Gas MeSH
- Adult MeSH
- Cholesterol, HDL blood MeSH
- Mass Spectrometry MeSH
- Hypercholesterolemia etiology MeSH
- Critical Illness MeSH
- Lanosterol blood MeSH
- Cholesterol, LDL blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Logistic Models MeSH
- Adolescent MeSH
- Critical Care MeSH
- Multiple Trauma blood MeSH
- Aged MeSH
- Squalene blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Cholesterol MeSH
- Cholesterol, HDL MeSH
- Lanosterol MeSH
- lathosterol MeSH Browser
- Cholesterol, LDL MeSH
- Squalene MeSH
BACKGROUND: The causes of hypocholesterolemia in the critically ill, including major trauma patients, have not yet been fully elucidated. OBJECTIVE: We tested the hypothesis that hypocholesterolemia is caused by decreased production of cholesterol precursors. DESIGN: Serum concentrations of squalene, lanosterol, and lathosterol were measured on admission, and then at 24 and 48 hours after injury using gas chromatography coupled with mass spectrometry. Serum concentrations of total low-density and high-density lipoprotein cholesterol were measured on admission and every day in the first week after injury. RESULTS: 83 consecutive patients with multiple trauma were examined. Significant drops in concentrations of lanosterol and lathosterol were found in the patients in comparison with the control group. The most profound drop was in lathosterol. CONCLUSION: Decreased synthesis of cholesterol precursors is the major cause of hypocholesterolemia in patients with multiple trauma. Lathosterol concentration is proposed as a marker of cholesterol synthesis.
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