Cercariae of the nasal bird schistosome Trichobilharzia regenti are able to penetrate into mammalian skin and migrate to the mouse central nervous system (CNS) causing tissue injury in certain cases. Our study shows that the severity of T. regenti pathologies in the CNS closely depends on the host immune status. During the primary infection of immunocompetent mice, the parasites evoked an acute inflammatory reaction in the skin and the CNS involving focal oedema and cellular infiltration of the tissue. Challenge infections resulted in the development of extensive inflammatory foci in the host skin which precluded the subsequent migration of the schistosomula to the CNS. On the other hand, during primary as well as challenge infections of immunodeficient mice (SCID), no significant immune response against the parasites was detected in any of the host organs examined; however, in contrast to immunocompetent mice, the infections were frequently manifested by severe leg paralysis.

Department of Tropical Medicine 3rd Clinic of Infectious and Tropical Diseases Faculty Hospital Bulovka 128 00 Prague 2 Czech Republic

Zobrazit více v PubMed

Can J Zool. 1975 Dec;53(12):1803-11 PubMed

Parasitol Res. 1991;77(7):642-4 PubMed

Am J Hyg. 1949 May;49(3):290-302 PubMed

Am J Trop Med Hyg. 1961 Nov;10:859-69 PubMed

Am J Trop Med Hyg. 1999 Nov;61(5):743-50 PubMed

J Helminthol. 1999 Sep;73(3):215-20 PubMed

Exp Parasitol. 1996 Jun;83(1):46-54 PubMed

Parasitology. 1999 Dec;119 ( Pt 6):577-81 PubMed

Parasitology. 1985 Aug;91 ( Pt 1):111-20 PubMed

J Parasitol. 1953 Jun;39(3):237-46 PubMed

S Afr Med J. 1991 Jun 1;79(11):680 PubMed

J Helminthol. 2002 Jun;76(2):137-41 PubMed

Parasitol Res. 2001 Aug;87(8):644-50 PubMed

Onderstepoort J Vet Res. 1986 Dec;53(4):209-11 PubMed

Parasitology. 1979 Aug;79(1):49-62 PubMed

Bull World Health Organ. 1996;74(2):159-63 PubMed

Parasite. 1998 Dec;5(4):349-57 PubMed

J Immunol. 2004 Mar 15;172(6):3766-74 PubMed

C R Acad Sci III. 1994 Jun;317(6):529-33 PubMed

Int J Parasitol. 2000 Jan;30(1):65-8 PubMed

Molecular identification of Trichobilharzia species in recreational waters in North-Eastern Poland

Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice

Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases

Nitric oxide and cytokine production by glial cells exposed in vitro to neuropathogenic schistosome Trichobilharzia regenti

Avian schistosomes and outbreaks of cercarial dermatitis

Cercarial dermatitis, a neglected allergic disease

Pathogenicity of Trichobilharzia spp. for Vertebrates

Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis

Trichobilharzia szidati: the lung phase of migration within avian and mammalian hosts