A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods
Language English Country Germany Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15544060
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase chemistry metabolism MeSH
- Chemical Warfare Agents pharmacology MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Rats MeSH
- Brain drug effects enzymology MeSH
- Obidoxime Chloride pharmacology MeSH
- Organophosphates pharmacology MeSH
- Organophosphorus Compounds pharmacology MeSH
- Oximes pharmacology MeSH
- Rats, Wistar MeSH
- Pralidoxime Compounds pharmacology MeSH
- Pyridinium Compounds pharmacology MeSH
- Cholinesterase Reactivators pharmacology MeSH
- Sarin pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 1,4-bis(2-hydroxyiminomethylpyridinium)butane MeSH Browser
- Acetylcholinesterase MeSH
- asoxime chloride MeSH Browser
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- cyclohexyl methylphosphonofluoridate MeSH Browser
- Obidoxime Chloride MeSH
- Organophosphates MeSH
- Organophosphorus Compounds MeSH
- Oximes MeSH
- pralidoxime MeSH Browser
- Pralidoxime Compounds MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- Sarin MeSH
- tabun MeSH Browser
The efficacy of a bispyridinium oxime 1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide, called K033, and of currently used oximes (pralidoxime, obidoxime, oxime HI-6), to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun cyclosarin) was tested by in vitro methods. The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. On the other hand, oxime K033 was more efficacious than oxime HI-6 in reactivating tabun-inhibited acetylcholinesterase. Thus, oxime K033 seems to be a relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, could be useful if no information about the type of nerve agent used was available.
