JavaScript is NOT enabled !

Please enable JavaScript.

Article

PubMed

This record comes from PubMed

Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue

Lipids. 2004 Dec ; 39 (12) : 1177-85.

ISSN 0024-4201
Source

Language English Country United States Media print

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid15736913

PubMed 15736913
DOI 10.1007/s11745-004-1345-9
Knihovny.cz E-resources

MeSH
Diet MeSH
Mice MeSH
Fatty Acids, Unsaturated therapeutic use MeSH
Obesity diet therapy etiology pathology MeSH
Fatty Acids, Omega-3 therapeutic use MeSH
Adipose Tissue pathology MeSH
Animals MeSH
Check Tag
Mice MeSH
Animals MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Fatty Acids, Unsaturated MeSH
Fatty Acids, Omega-3 MeSH

Omega-3 PUFA of marine origin reduce adiposity in animals fed a high-fat diet. Our aim was to learn whether EPA and DHA could limit development of obesity and reduce cellularity of adipose tissue and whether other dietary FA could influence the effect of EPA/DHA. Weight gain induced by composite high-fat diet in C57BL/6J mice was limited when the content of EPA/DHA was increased from 1 to 12% (wt/wt) of dietary lipids. Accumulation of adipose tissue was reduced, especially of the epididymal fat. Low ratio of EPA to DHA promoted the effect. A higher dose of EPA/DHA was required to reduce adiposity when admixed to diets that did not promote obesity, the semisynthetic high-fat diets rich in EFA, either alpha-linolenic acid (ALA, 18:3 n-3, the precursor of EPA and DHA) or linoleic (18:2 n-6) acid. Quantification of adipose tissue DNA revealed that except for the diet rich in ALA the reduction of epididymal fat was associated with 34-50% depression of tissue cellularity, similar to the 30% caloric restriction in the case of the high-fat composite diet. Changes in plasma markers and adipose gene expression indicated improvement of lipid and glucose metabolism due to EPA/DHA even in the context of the diet rich in ALA. Our results document augmentation of the antiadipogenic effect of EPA/DHA during development of obesity and suggest that EPA/DHA could reduce accumulation of body fat by limiting both hypertrophy and hyperplasia of fat cells. Increased dietary intake of EPA/DHA may be beneficial regardless of the ALA intake.

Department of Adipose Tissue Biology and Centre for Integrated Genomics Institute of Physiology Academy of Sciences of the Czech Republic 142 20 Prague Czech Republic

Erratum In

Lipids. 2005 Jan;40(1):115 PubMed

See more in PubMed

Exp Biol Med (Maywood). 2003 Nov;228(10 ):1118-23 PubMed

Lipids. 2002 Dec;37(12):1113-23 PubMed

Ann Nutr Metab. 1999;43(2):86-97 PubMed

J Nat Prod. 2001 Jun;64(6):745-9 PubMed

Metabolism. 1990 Mar;39(3):217-9 PubMed

Int J Obes Relat Metab Disord. 1997 Nov;21(11):955-62 PubMed

J Nutr. 2001 Oct;131(10 ):2636-42 PubMed

J Lipid Res. 2003 Feb;44(2):271-9 PubMed