Effects of angiotensin-(1-7) blockade on renal function in rats with enhanced intrarenal Ang II activity
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15780097
DOI
10.1111/j.1523-1755.2005.00222.x
PII: S0085-2538(15)50600-5
Knihovny.cz E-zdroje
- MeSH
- angiotensin I farmakologie MeSH
- angiotensin II farmakologie fyziologie MeSH
- diuréza účinky léků MeSH
- geneticky modifikovaná zvířata MeSH
- hodnoty glomerulární filtrace účinky léků fyziologie MeSH
- krysa rodu Rattus MeSH
- ledviny účinky léků fyziologie MeSH
- peptidové fragmenty farmakologie MeSH
- potkani Sprague-Dawley MeSH
- renin-angiotensin systém MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- angiotensin I (1-7) MeSH Prohlížeč
- angiotensin I MeSH
- angiotensin II MeSH
- peptidové fragmenty MeSH
BACKGROUND: Increasing evidence suggests that angiotensin-(1-7) [Ang-(1-7)] acts as an endogenous antagonist of Ang II when the renin-angiotensin system (RAS) is activated. In the present study, we therefore compared the effects of acute intrarenal (i.r.) Ang-(1-7) receptor blockade on renal function under conditions of normal and increased intrarenal Ang II concentration. METHODS: Salt-replete Hannover-Sprague Dawley rats (HanSD) served as control animals. As models with enhanced action of Ang II we first used transgenic rats harboring the Ren-2 renin gene (TGR), second, Ang II-infused rats, third, 2-kidney, 1-clip (2K1C) hypertensive rats on normal salt intake, and fourth, salt-depleted TGR and HanSD. RESULTS: I.r. Ang-(1-7) receptor blockade elicited significant decreases in glomerular filtration rate (GFR), renal plasma flow (RPF), and sodium excretion in 2K1C rats, and in salt-depleted TGR and HanSD. In contrast, i.r. Ang-(1-7) receptor blockade did not significantly change GFR, RPF, and sodium excretion in salt-replete TGR and HanSD, or in Ang II-infused rats. CONCLUSION: These findings suggest that under conditions of normal intrarenal RAS activity and increased intrarenal Ang II action by infusion of Ang II or by insertion of a renin gene in salt-replete conditions, Ang-(1-7) is not an important factor in the regulation of renal function. In contrast, under conditions of endogenous RAS activation due to clipping of the renal artery or to sodium restriction, Ang-(1-7) serves as opponent of the vasoconstrictor actions of Ang II.
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Research on Experimental Hypertension in Prague (1966-2009)