Pax genes in eye development and evolution
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15950457
DOI
10.1016/j.gde.2005.05.001
PII: S0959-437X(05)00091-2
Knihovny.cz E-resources
- MeSH
- Homeodomain Proteins genetics MeSH
- Models, Genetic MeSH
- Evolution, Molecular * MeSH
- Morphogenesis genetics MeSH
- Eye embryology growth & development metabolism MeSH
- Eye Proteins genetics MeSH
- Repressor Proteins genetics MeSH
- PAX6 Transcription Factor MeSH
- Paired Box Transcription Factors MeSH
- Gene Expression Regulation, Developmental MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Homeodomain Proteins MeSH
- Eye Proteins MeSH
- Repressor Proteins MeSH
- PAX6 Transcription Factor MeSH
- Paired Box Transcription Factors MeSH
Animal eyes with widely different anatomical designs have long been thought to arise independently, multiple times during evolution. This view was challenged about a decade ago by the landmark discoveries that Pax6, a highly conserved transcription factor, plays a key role in eye morphogenesis in both flies and mammals. Since then, more evidence has emerged in favour of the redeployment of Pax6 and some other developmental control genes within the genetic program underlying eye formation throughout the animal kingdom. Recent work has indicated that other members of the Pax gene family play a pivotal role in eye morphogenesis. The Eye gone gene regulates eye growth in Drosophila, whereas the PaxB gene is implicated in visual system development in jellyfish, the most basal organism possessing eyes.
References provided by Crossref.org
Ancestral role of Pax6 in chordate brain regionalization
Eye evolution: common use and independent recruitment of genetic components
