Analysis of genetic events in 17p13 and 9p21 regions supports predominant monoclonal origin of multifocal and recurrent bladder cancer
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16343743
DOI
10.1016/j.canlet.2005.10.036
PII: S0304-3835(05)00973-0
Knihovny.cz E-resources
- MeSH
- Carcinoma, Transitional Cell genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 17 * MeSH
- Chromosomes, Human, Pair 9 * MeSH
- Antibodies, Monoclonal chemistry MeSH
- Mutation * MeSH
- Tumor Suppressor Protein p53 biosynthesis genetics MeSH
- Urinary Bladder Neoplasms genetics MeSH
- Disease Progression MeSH
- Recurrence MeSH
- Aged MeSH
- Loss of Heterozygosity * MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Monoclonal MeSH
- Tumor Suppressor Protein p53 MeSH
Clonality was tested in 86 tumours from 25 patients with recurrent and multifocal superficial bladder transitional cell carcinomas (TCCs) using the analysis of TP53 mutations and of LOH in the 17p13 and 9p21 regions. Tumours from the majority of individuals showed either absence or presence of the same TP53 mutation and/or an identical LOH pattern, with the same allele lost in all tumours. Only two pairs of tumours from two patients had discordant findings, which were incompatible with monoclonality. Therefore, our results rather support the monoclonal model of development of highly recurrent superficial bladder TCCs.
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