Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16792471
DOI
10.33549/physiolres.930980
PII: 980
Knihovny.cz E-resources
- MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Electrophysiology MeSH
- Muscle, Skeletal drug effects innervation physiology MeSH
- Rats MeSH
- Quaternary Ammonium Compounds chemistry pharmacology MeSH
- Molecular Structure MeSH
- Motor Endplate drug effects physiology MeSH
- Synaptic Transmission drug effects physiology MeSH
- Rats, Wistar MeSH
- In Vitro Techniques MeSH
- Uracil analogs & derivatives chemistry pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- C-547 compound MeSH Browser
- Cholinesterase Inhibitors MeSH
- Quaternary Ammonium Compounds MeSH
- Uracil MeSH
A novel derivative of 6-methyluracil, C-547, increased the amplitude and prolonged the duration of miniature endplate currents (MEPCs) which is typical for acetylcholinesterase inhibition. In the soleus and extensor digitorum longus significant potentiation was detected at nanomolar concentrations. In contrast, in the diaphragm muscle, the increase in the amplitudes of the MEPCs and the decay time constant appeared only when the concentration of C-547 was elevated to 1 x 10(-7) M. Possible consequences for the exploitation of this drug, which can selectively inhibit AChE in particular synapses, are discussed.
References provided by Crossref.org
From Frog Muscle to Brain Neurons: Joys and Sorrows in Neuroscience
